2. Immunology/Inflammation MAPK/ERK Pathway Apoptosis
  3. NOD-like Receptor (NLR) p38 MAPK Apoptosis
  4. RP-220

RP-220 is a renalase peptide targeting NLRP3. RP220 has anti-inflammatory and anti-apoptotic activities. RP220 inhibits renal tubular epithelial cells apoptosis with alkaline insult by activating MAPK signaling pathway. RP220 significantly inhibits NLRP3 expression and reduces macrophage infiltration and kidney tissue damage in acute kidney injury (AKI) mice model. RP-220 can be uses for systemic lupus erythematosus (SLE) and its complication lupus nephritis (LN) research.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

RP-220

RP-220 Chemical Structure

CAS No. : 1541177-35-8

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RP-220 Related Antibodies

Top Publications Citing Use of Products

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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Description

RP-220 is a renalase peptide targeting NLRP3. RP220 has anti-inflammatory and anti-apoptotic activities. RP220 inhibits renal tubular epithelial cells apoptosis with alkaline insult by activating MAPK signaling pathway. RP220 significantly inhibits NLRP3 expression and reduces macrophage infiltration and kidney tissue damage in acute kidney injury (AKI) mice model. RP-220 can be uses for systemic lupus erythematosus (SLE) and its complication lupus nephritis (LN) research[1].

IC50 & Target[1]

NLRP3

 

Molecular Weight

2308.61

Formula

C98H166N30O32S
CAS No.
Sequence

Cys-Ile-Arg-Phe-Val-Ser-Ile-Asp-Asn-Lys-Lys-Arg-Asn-Ile-Glu-Ser-Ser-Glu-Ile-Gly
Sequence Shortening

CIRFVSIDNKKRNIESSEIG
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Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O : 1.96 mg/mL (0.85 mM; ultrasonic and adjust pH to 3 with CH3COOH)

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RP-220 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RP-2201541177-35-8RP220RP 220NOD-like Receptor (NLR)p38 MAPKApoptosisRenalase peptideNLRP3Anti-inflammatoryAnti-apoptoticMAPKAKI mice modelSystemic lupus erythematosusSLELupus nephritisLNInhibitorinhibitorinhibit

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