2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation
  3. Glutathione Peroxidase STING
  4. Anti-Mouse myeloperoxidase/MPO Antibody (6G4)

Anti-Mouse myeloperoxidase/MPO Antibody (6G4) 

Cat. No.: HY-P990181 Purity: 95.00%
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Anti-Mouse myeloperoxidase/MPO Antibody (6G4) is an anti-mouse myeloperoxidase/MPO IgG2c monoclonal antibody. Anti-Mouse myeloperoxidase/MPO Antibody (6G4) can activate the cGAS/STING pathway. Anti-Mouse myeloperoxidase/MPO Antibody (6G4) induces acute and chronic kidney injury in mice. Anti-Mouse myeloperoxidase/MPO Antibody (6G4) is often used in the construction of inflammation conditions models such as anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV).

For research use only. We do not sell to patients.

Anti-Mouse myeloperoxidase/MPO Antibody (6G4) Chemical Structure

Anti-Mouse myeloperoxidase/MPO Antibody (6G4) Chemical Structure

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Description

Anti-Mouse myeloperoxidase/MPO Antibody (6G4) is an anti-mouse myeloperoxidase/MPO IgG2c monoclonal antibody. Anti-Mouse myeloperoxidase/MPO Antibody (6G4) can activate the cGAS/STING pathway. Anti-Mouse myeloperoxidase/MPO Antibody (6G4) induces acute and chronic kidney injury in mice. Anti-Mouse myeloperoxidase/MPO Antibody (6G4) is often used in the construction of inflammation conditions models such as anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV)[1][2].

IC50 & Target

myeloperoxidase/MPO
In Vitro

Anti-Mouse myeloperoxidase/MPO Antibody (6G4) (5 μg/mL, 30 min) can bind to the extracellular DNA released by activated neutrophils to form DNA/MPO/IgG immune complexes in neutrophils from bone marrow of C57BL/6J mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse myeloperoxidase/MPO Antibody (6G4) Related Antibodies
In Vivo

Anti-Mouse myeloperoxidase/MPO Antibody (6G4) (0.75 mg, i.p., single dose, on day 5 after treatment with anti-rat glomerular basement membrane serum) successfully simulates anti neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) in female C57BL/6J mice[1].
Anti-Mouse myeloperoxidase/MPO Antibody (6G4) (1 mg, i.p., single dose) successfully establishes a novel mouse model of pulmonary vasculitis in female C57BL/6J mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6J mice (8-10 weeks)[1]
Dosage: 0.75 mg, combined with anti-rat glomerular basement membrane serum (100 μL, i.v., on day 0), anti-MPO mAb (6D1) (0.75 mg) and LPS (0.5 μg/g) (HY-D1056)
Administration: Intraperitoneal injection (i.p.), single dose on day 5
Result: Caused 70% of glomerular necrosis or crescent formation during the acute phase.
Caused 70% of glomerular scarring during the chronic phase.
Increased the infiltration of neutrophils and macrophages in the acute phase and T cells in the chronic phase.
Significantly upregulated inflammatory factors and ECM molecules.
Animal Model: Female C57BL/6J mice (8-12 weeks)[2]
Dosage: 1 mg, combined with fMLP (10 μg, intratracheal injection (i.t.)) (HY-P0224), LPS (10 μg, intratracheal injection (i.t.)) (HY-D1056) and anti-MPO mAb (6D1) (0.5 mg)
Administration: Intraperitoneal injection (i.p.), single dose
Result: Relied on the cGAS/STING/IFN-I pathway to synergistically induce severe pulmonary hemorrhage and inflammation with bacterial ligands.
Gene ID

17523  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse myeloperoxidase/MPO Antibody (6G4)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 95.00%

COA (232 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Anti-Mouse myeloperoxidase/MPO Antibody (6G4) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse myeloperoxidase/MPO Antibody (6G4)Glutathione PeroxidaseSTINGStimulator of Interferon GenesTMEM173MITAERISMPYSmyeloperoxidaseMPOcGAS/STINGinflammationAAVInhibitorinhibitorinhibit

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