2. Cytoskeleton
  3. Collagen
  4. Tetrapeptide-21

Tetrapeptide-21 is a bioactive peptide composed of four amino acids. Tetrapeptide-21 effectively enhances the vitality of human dermal fibroblasts. Tetrapeptide-21 upregulates the expression of key extracellular matrix (ECM) genes and promotes the synthesis of ECM proteins (such as type I collagen, hyaluronic acid synthase 1, and fibronectin). Tetrapeptide-21 has the efficacy of anti-wrinkle and improving skin elasticity, and has been reported to be used as a cosmetic ingredient.

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Custom Peptide Synthesis

Tetrapeptide-21

Tetrapeptide-21 Chemical Structure

CAS No. : 960608-17-7

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Based on 1 publication(s) in Google Scholar

Tetrapeptide-21 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Tetrapeptide-21 is a bioactive peptide composed of four amino acids. Tetrapeptide-21 effectively enhances the vitality of human dermal fibroblasts. Tetrapeptide-21 upregulates the expression of key extracellular matrix (ECM) genes and promotes the synthesis of ECM proteins (such as type I collagen, hyaluronic acid synthase 1, and fibronectin). Tetrapeptide-21 has the efficacy of anti-wrinkle and improving skin elasticity, and has been reported to be used as a cosmetic ingredient[1][2].

In Vitro

Tetrapeptide-21 (0-72 h) reduces cell viability in the later stage (48-72 h), showing potential cytotoxicity, however, the synergistic injectable platelet-rich fibrin (i-PRF) can reverse the toxic effect of the peptide and significantly enhance cell viability and proliferation ability in FBH cells[1].
Tetrapeptide-21 (6-72 h) increases the gene expression of COL1A1, and when used in combination with i-RPF, it also upregulated the expressions of FN1 and HAS1 in FBH cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tetrapeptide-21 Related Antibodies
Molecular Weight

389.40

Formula

C15H27N5O7
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Gly-Glu-Lys-Gly
Sequence Shortening

GEKG
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 200 mg/mL (513.61 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5681 mL 12.8403 mL 25.6805 mL
5 mM 0.5136 mL 2.5681 mL 5.1361 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.5681 mL 12.8403 mL 25.6805 mL 64.2013 mL
5 mM 0.5136 mL 2.5681 mL 5.1361 mL 12.8403 mL
10 mM 0.2568 mL 1.2840 mL 2.5681 mL 6.4201 mL
15 mM 0.1712 mL 0.8560 mL 1.7120 mL 4.2801 mL
20 mM 0.1284 mL 0.6420 mL 1.2840 mL 3.2101 mL
25 mM 0.1027 mL 0.5136 mL 1.0272 mL 2.5681 mL
30 mM 0.0856 mL 0.4280 mL 0.8560 mL 2.1400 mL
40 mM 0.0642 mL 0.3210 mL 0.6420 mL 1.6050 mL
50 mM 0.0514 mL 0.2568 mL 0.5136 mL 1.2840 mL
60 mM 0.0428 mL 0.2140 mL 0.4280 mL 1.0700 mL
80 mM 0.0321 mL 0.1605 mL 0.3210 mL 0.8025 mL
100 mM 0.0257 mL 0.1284 mL 0.2568 mL 0.6420 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Tetrapeptide-21 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tetrapeptide-21960608-17-7Tetrapeptide21Tetrapeptide 21Collagenplatelet-rich fibrinpeptidesfibroblastsin vitro techniquesgene expressioncollagen type Ihyaluronan synthasesfibronectinsrejuvenationdermisInhibitorinhibitorinhibit

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