Plantaricin A  (Synonyms: PlnA)

Plantaricin A is an antimicrobial peptide that can be derived from Lactobacillus plantarum. Plantaricin A has a synergistic effect with Ciprofloxacin. PlnA shows anti-microbial activity. Plantaricin A increases the membrane potential of S. aureus and the level of intracellular ROS. Plantaricin A inhibits the function of the efflux pump by binding it and altering the structure of MepA, NorA, and LmrS. Plantaricin A significantly relieves inflammation, and promotes wound healing. Plantaricin A permeabilizes cancerous rat pituitary cells[^1][2].

Plantaricin A (12.5 μg/mL, 12 h) enhances the activity of Ciprofloxacin (CIP) (HY-B0356) and Trimethoprim (HY-B0510) in ATCC 29213, which effectively inhibits the growth of S. aureus at sublethal concentrations^[1].
Plantaricin A (12.5 μg/mL, 2 h) increases the membrane potential of S. aureus and the level of intracellular ROS^[1].
Plantaricin A (12.5 μg/mL) exerts a synergistic effect with CIP in S. aureus by inhibiting the function of efflux pumps^[1].
Plantaricin A (1-50 μM, 60 min) induces the cell death in the cancerous lymphoid Reh, Jurkat cells, normal B and T cells dose-dependently^[2].
Plantaricin A (20-50 μM, 50 s) induces a rapidly developing membrane permeabilization followed by membrane disruption or cell lysis in PC12 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Plantaricin A (12.5 μg/mL, topical delivery, daily for 7 days) inhibits methicillin-resistant S. aureus (MRSA) on wound surfaces in the mice infected with CIP-resistant S. aureus-NorA when combined with CIP^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2985.55

C₁₄₀H₂₂₂N₃₆O₃₄S

131463-18-8

Solid

White to off-white

Lys-Ser-Ser-Ala-Tyr-Ser-Leu-Gln-Met-Gly-Ala-Thr-Ala-Ile-Lys-Gln-Val-Lys-Lys-Leu-Phe-Lys-Lys-Trp-Gly-Trp

KSSAYSLQMGATAIKQVKKLFKKWGW

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Meng F, et al. Plantaricin A reverses resistance to ciprofloxacin of multidrug-resistant Staphylococcus aureus by inhibiting efflux pumps. Environ Microbiol. 2022 Oct;24(10):4818-4833.  [Content Brief]

  [2]. Sand SL, et al. Plantaricin A, a peptide pheromone produced by Lactobacillus plantarum, permeabilizes the cell membrane of both normal and cancerous lymphocytes and neuronal cells. Peptides. 2010 Jul;31(7):1237-44.  [Content Brief]