2. GPCR/G Protein
  3. GLP Receptor GCGR
  4. Pemvidutide

Pemvidutide (ALT-801) is a GLP-1R/GCGR dual agonist, shows striking reductions in body weight, liver fat and serum lipids. Pemvidutide can be used in non-alcoholic steatohepatitis (NASH) and obesity research.

For research use only. We do not sell to patients.

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Pemvidutide Chemical Structure

Pemvidutide Chemical Structure

CAS No. : 2538014-94-5

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Description

Pemvidutide (ALT-801) is a GLP-1R/GCGR dual agonist, shows striking reductions in body weight, liver fat and serum lipids. Pemvidutide can be used in non-alcoholic steatohepatitis (NASH) and obesity research[1].

In Vivo

Pemvidutide (subcutaneous injection; 5 or 10 nmol/kg; once daily; 12 w) treatment improves NASH (nonalcoholic steatohepatitis) outcomes in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL6/J mice (with biopsy-confirmed NAS score after 29 weeks on a HFFC diet)[1]
Dosage: 5 or 10 nmol/kg
Administration: Subcutaneous injection; 5 or 10 nmol/kg; once daily; 12 weeks
Result: Lowered hepatic lipids, liver weight, biomarkers of liver injury (plasma ALT and AST), the inflammation marker galactin-3, the fibrosis marker Col1a1, and the NAS score.
Molecular Weight

3873.35

Formula

C182H275N39O54
CAS No.
Sequence

His-{Aib}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Glu--{Lys(N6-(1-O-(17-Carboxyheptadecyl)-D-Glucopyranuronoyl))}-Ala-Ala-Lys-Glu-Phe-Ile-Gln-Trp-Leu-Leu-Gln-Thr-NH2 (Lactam bridge: Glu-16;Lys-20)
Sequence Shortening

H-{Aib}-QGTFTSDYSKYLDE-{Lys(N6-(1-O-(17-Carboxyheptadecyl)-D-Glucopyranuronoyl))}-AAKEFIQWLLQT-NH2 (Lactam bridge: Glu-16;Lys-20)
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Pemvidutide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pemvidutide2538014-94-5ALT-801ALT801ALT 801GLP ReceptorGCGRGlucagon Receptorbody weightliver fatserum lipidnon-alcoholic steatohepatitisNASHobesityInhibitorinhibitorinhibit

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