2. Others Apoptosis
  3. Drug Derivative Apoptosis
  4. TQFL13

TQFL13 is derivative of Thymoquinone (TQ) (HY-D0803) with potent anti-breast cancer activity. TQFL13 exhibits higher cytotoxicity against breast cancer cells (BT549, MDA-MB-231, 4T1). TQFL13 increases apoptosis and blocks the cell cycle at S and G2/G1 phases in breast cancer cells. TQFL13 shows dose-dependent anti-tumor efficacy in mouse breast cancer allograft model. TQFL13 can be used for the study of breast cancer.

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TQFL13

TQFL13 Chemical Structure

CAS No. : 2822560-46-1

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TQFL13 Related Antibodies

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Description

TQFL13 is derivative of Thymoquinone (TQ) (HY-D0803) with potent anti-breast cancer activity. TQFL13 exhibits higher cytotoxicity against breast cancer cells (BT549, MDA-MB-231, 4T1). TQFL13 increases apoptosis and blocks the cell cycle at S and G2/G1 phases in breast cancer cells. TQFL13 shows dose-dependent anti-tumor efficacy in mouse breast cancer allograft model. TQFL13 can be used for the study of breast cancer[1].

In Vitro

TQFL13 (0-160 μM, 24 h) exerts cytotoxic activity against BT549, MDA-MB-231, 4T1 breast cancer cells and normal MCF-10A cells, with IC50 values of 23.80 μM, 37.55 μM, 17.59 μM, and > 100 μM, respectively[1].
TQFL13 (48 h) displays anti-viability activity against BT549, MDA-MB-231, 4T1 breast cancer cells and normal MCF-10A cells, with IC50 values of 12.35 μM, 12.14 μM, 12.21 μM, and >100 μM, respectively[1].
TQFL13 (0-20 μM, 24 h) increases apoptosis in 4 T1 cells and blocks the cell cycle at S and G2/G1 phases in BT549 and MDA-MB-231 breast cancer cells[1].
TQFL13 (2.5-5 μM, 0-54 h) inhibits 4 T1 cell growth, migration, and invasion[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TQFL13 Related Antibodies

Apoptosis Analysis[1]

Cell Line: 4 T1 and MDA-MB-231 breast cancer cells
Concentration: 0, 5, 10, 20 μM
Incubation Time: 24 h
Result: Induced the apoptosis.
Reduced the full-length PARP and BCL-2.
Increased the level of BAX.

Cell Cycle Analysis[1]

Cell Line: BT549 and MDA-MB-231 breast cancer cells
Concentration: 0, 5, 10, 20 μM
Incubation Time: 24 h
Result: Blocked the cell cycle at S and G2/G1 phases.
Downregulated the level of CyclinB1, CyclinD1and p53.
Upregulated the level of phosphorylated p53 (ser15).
In Vivo

TQFL13 (3.75-15 mg/kg, i.p., starts 4 days after 4T1 cell inoculation into mammary fat pads, continues until day 30) shows anti-tumor efficacy in BALB/c mouse breast cancer allograft model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4T1 mouse breast cancer cells were injected into the fourth mammary fat pads of female BALB/c mice to construct a breast cancer lung metastasis model [1]
Dosage: 3.75, 7.5, 15 mg/kg
Administration: i.p., starts 4 days after 4T1 cell inoculation into mammary fat pads, continues until day 30
Result: Showed dose-dependent anti-tumor efficacy.
Showed no significant changes in body weight.
Altered the morphology of breast tumor cells.
Exerted anti-tumor activity by regulating cell apoptosis and cell cycle signaling pathways.
Molecular Weight

357.40

Formula

C20H23NO5
CAS No.
SMILES

COC1=CC=C(C(OC)=C1OC)/C=N/C2=C(C(C=C(C2=O)C(C)C)=O)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TQFL13 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TQFL132822560-46-1TQFL 13TQFL-13Drug DerivativeApoptosisDrug derivativeBreast cancerThymoquinoneTQ derivativeInhibitorinhibitorinhibit

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