2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Microtubule/Tubulin Apoptosis Reactive Oxygen Species (ROS)
  4. Tubulin/CDC5L-IN-1

Tubulin/CDC5L-IN-1 is a Tubulin/CDC5L dual inhibitor. Tubulin/CDC5L-IN-1 targets to CDCL5 with a KD of 103.7 μM. Tubulin/CDC5L-IN-1 can inhibit multiple cancer cell proliferation and induce G2/M phase arrest. Tubulin/CDC5L-IN-1 induce cell apoptosis and ROS production. Tubulin/CDC5L-IN-1 exhibits antiangiogenic effects. Tubulin/CDC5L-IN-1 can be used for the research of cancer, such as colon carcinoma.

For research use only. We do not sell to patients.

Tubulin/CDC5L-IN-1

Tubulin/CDC5L-IN-1 Chemical Structure

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Tubulin/CDC5L-IN-1 Related Antibodies

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Description

Tubulin/CDC5L-IN-1 is a Tubulin/CDC5L dual inhibitor. Tubulin/CDC5L-IN-1 targets to CDCL5 with a KD of 103.7 μM. Tubulin/CDC5L-IN-1 can inhibit multiple cancer cell proliferation and induce G2/M phase arrest. Tubulin/CDC5L-IN-1 induce cell apoptosis and ROS production. Tubulin/CDC5L-IN-1 exhibits antiangiogenic effects. Tubulin/CDC5L-IN-1 can be used for the research of cancer, such as colon carcinoma[1].

In Vitro

Tubulin/CDC5L-IN-1 (Compound 11i) (48 h) inhibits HeLa, HCT 116, A2780, and A549 cells proliferation with IC50 values of 0.046, 0.035, 0.096 and 0.112 μM[1].
Tubulin/CDC5L-IN-1 shows antiproliferative efficacy in drug-resistant cancer cells with IC50 ranging from 0.089-0.172 μM[1].
Tubulin/CDC5L-IN-1 (1-100 μM, 0-30 mins) inhibits the microtubule assembly with an IC50 of 28.8 μM[1].
Tubulin/CDC5L-IN-1 (0.125-0.05 μM, 24 h) inhibits colony formation in HeLa and HCT 116 cells[1].
Tubulin/CDC5L-IN-1 (0.125-0.1 μM, 12 h) induces G2/M phase arrest in HCT 116 cells[1].
Tubulin/CDC5L-IN-1 (0.05-0.2 μM, 24 h) induces apoptosis and ROS production in HCT 116 cells[1].
Tubulin/CDC5L-IN-1 (0.05-0.2 μM, 4 h) inhibits capillary tube-like formation in HUVECs[1].
Tubulin/CDC5L-IN-1 (5 μM) inhibits DNA-dependent protein kinase and cell division cycle 7[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin/CDC5L-IN-1 Related Antibodies

Cell Cycle Analysis[1]

Cell Line: HCT 116 cells
Concentration: 0.125, 0.05 and 0.1 μM
Incubation Time: 12 h
Result: Increased cells in the G2/M phase.
Increased the phosphorylation level of histone H3 (PHH3) at Ser10.
In Vivo

Tubulin/CDC5L-IN-1 (Compound 11i) (7.5-20 mg/kg, i.p., every 2 days) inhibits tumor growth in HCT116 xenograft mice models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HCT116 xenograft mice models[1]
Dosage: 7.5, 10 and 20 mg/kg
Administration: Intraperitoneally injection, every 2 days
Result: Reduced tumor weight and volume.
Had no body weight loss.
Decreased Ki67-positive cells and reduced tumor microvessel density.
Had no histopathological changes in the heart, liver, spleen, lungs, or kidneys.
Molecular Weight

580.59

Formula

C28H32N6O8
SMILES

CC(C)C[C@H](C(O)=O)NC(OC1=CC(C2=NC(N)=C3C(N(C4=CC(OC)=C(OC)C(OC)=C4)N=C3)=N2)=CC=C1OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tubulin/CDC5L-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin/CDC5L-IN-1Microtubule/TubulinApoptosisReactive Oxygen Species (ROS)TubulinCDC5LROSColon carcinomaHeLaHCT 116A2780A549Inhibitorinhibitorinhibit

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