Ferroptosis inducer-10 

Ferroptosis inducer-10 is a ferroptosis inducer. Ferroptosis inducer-10 can inhibit A549 cells growth with an IC₅₀ of 0.76 μM. Ferroptosis inducer-10 can deplete GSH, elevate ROS and MDA, and downregulate GPX4 expression. Ferroptosis inducer-10 can induce cell G2/M phase and inhibit migration. Ferroptosis inducer-10 can be used for the research of cancer, such as non-small lung cancer^[1].

Ferroptosis inducer-10 (Compound I-21) shows antiproliferative activity in A549, HT-1080, MCF-7, Panc-02 and PC-3 cells with IC₅₀ values of 0.76, 1.03, 4.86, 3.41 and 1.34 μM, respectively^[1].
Ferroptosis inducer-10 shows no noticeable toxicity toward HUVEC cells (IC₅₀ = 24.66 μM) ^[1].
Ferroptosis inducer-10 (0.5-4 μM) increases ROS and MDA levels and decreases GSH levels in A549 cells^[1] Ferroptosis inducer-10 (0.5-4 μM, 12 h) increases Fe²⁺ levels in A549 cells^[1].
Ferroptosis inducer-10 (0.5-4 μM) induces cells crumpling and fragmentation in A549 cells^[1].
Ferroptosis inducer-10 (0.5-2 μM, 12-24 h) downregulates GPX4 levels in A549 cells^[1].
Ferroptosis inducer-10 (1-4 μM, 24 h) induces G2/M phase arrest in A549 cells^[1].
Ferroptosis inducer-10 (0.5-2 μM, 7 days) reduces form colonies in A549 cells^[1].
Ferroptosis inducer-10 (0.5-4 μM, 48 h) inhibits migration in A549 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

302.33

C₁₉H₁₄N₂O₂

O=C1C(NC2=CC=CC3=C2C=CC=N3)CC(C4=CC=CC=C41)=O

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• [1]. Yang H, et al. Scaffold-leaping optimization of naphthoquinone derivatives as ferroptosis inducer against non-small lung cancer. Bioorg Med Chem Lett. 2025 Aug 7;129:130360.  [Content Brief]