2. GPCR/G Protein
  3. Apelin Receptor (APJ)
  4. Apelin-13

Apelin-13 is an endogenous ligand for the G-protein coupled receptor angiotensin II protein J (APJ), activating this G protein-coupled receptor with an EC 50 value of 0.37 nM. Apelin-13 is widely distributed in the central and peripheral nervous systems. Apelin-13 has vasodilatory and antihypertensive effects. Apelin-13 also can be used for researching type 2 diabetes and metabolic syndrome.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Apelin-13 Chemical Structure

Apelin-13 Chemical Structure

CAS No. : 217082-58-1

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Based on 8 publication(s) in Google Scholar

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Apelin-13 Related Antibodies

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Description

Apelin-13 is an endogenous ligand for the G-protein coupled receptor angiotensin II protein J (APJ), activating this G protein-coupled receptor with an EC 50 value of 0.37 nM. Apelin-13 is widely distributed in the central and peripheral nervous systems. Apelin-13 has vasodilatory and antihypertensive effects. Apelin-13 also can be used for researching type 2 diabetes and metabolic syndrome[1][2][3].

IC50 & Target

IC50: 0.37 nM (APJ)[1]
In Vivo

Apelin-13 (200 µg/kg; IP, daily for 4 weeks) improves cardiac function, improves insulin resistance, improves lipid metabolism, significantly decreases TNF-α and leptin on serum, induces the expression of Apelin-12 in serum and markedly elevates GLUT4 and p-AMPKα2 levels[2].
Apelin-13 (10 and 100 μM; ICV, single dosage) increases the spontaneous discharges in the majority of pallidal neurons[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Goto-Kakizaki (GK) rats (12 weeks old; 240-280 g; fed with a high-fat diet: 66.5% standard chow, 10% lard, 20% sucrose, 2.5% cholesterol and 1% pig bile salt)[2]
Dosage: 200 µg/kg
Administration: IP, daily for 4 weeks
Result: Significantly decreased heart rate; lowered the levels of fasting plasma glucose (FPG), fasting insulin (FINS) and homeostasis model assessment for insulin resistancey (HOMA-IR); decreased serum levels of total cholesterol (TC), triglyceride (TG) and low density lipoprotein-cholesterol (LDL-C) and increased high density lipoprotein-cholesterol (HDL-C); decreased NO level, cNOS activity, TNF-α and leptin in serum; induced the expression of Apelin-12.
Animal Model: Adult Wistar rats (SPF, 8-10 weeks, 240-280 g)[4]
Dosage: 10 and100 μM
Administration: ICV, single dosage
Result: Increased the spontaneous discharges in the majority of pallidal neurons.
Clinical Trial
Molecular Weight

1550.83

Formula

C69H111N23O16S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe
Sequence Shortening

QRPRLSHKGPMPF
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (64.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6448 mL 3.2241 mL 6.4482 mL
5 mM 0.1290 mL 0.6448 mL 1.2896 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6448 mL 3.2241 mL 6.4482 mL 16.1204 mL
5 mM 0.1290 mL 0.6448 mL 1.2896 mL 3.2241 mL
10 mM 0.0645 mL 0.3224 mL 0.6448 mL 1.6120 mL
15 mM 0.0430 mL 0.2149 mL 0.4299 mL 1.0747 mL
20 mM 0.0322 mL 0.1612 mL 0.3224 mL 0.8060 mL
25 mM 0.0258 mL 0.1290 mL 0.2579 mL 0.6448 mL
30 mM 0.0215 mL 0.1075 mL 0.2149 mL 0.5373 mL
40 mM 0.0161 mL 0.0806 mL 0.1612 mL 0.4030 mL
50 mM 0.0129 mL 0.0645 mL 0.1290 mL 0.3224 mL
60 mM 0.0107 mL 0.0537 mL 0.1075 mL 0.2687 mL
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Apelin-13 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apelin-13217082-58-1Apelin13Apelin 13Apelin Receptor (APJ)nervous systemsvasodilatoryantihypertensivediabetesmetabolic syndromeinsulin resistancelipidpallidal neuronsGoto-Kakizaki ratWistar ratInhibitorinhibitorinhibit

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