2. Apoptosis
  3. TNF Receptor
  4. Anti-Mouse TL1A/TNFSF15 Antibody (5G4.6)

Anti-Mouse TL1A/TNFSF15 Antibody (5G4.6) 

Cat. No.: HY-P990151 Purity: 95.00%
COA
SDS
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Anti-Mouse TL1A/TNFSF15 Antibody (5G4.6) is an anti-mouse TL1A/TNFSF15 IgG monoclonal antibody. Anti-Mouse TL1A/TNFSF15 Antibody (5G4.6) can reduce TL1A levels and block TL1A-DR3 interactions. Anti-Mouse TL1A/TNFSF15 Antibody (5G4.6) can be used for research on inflammation conditions such as colitis and collagen-induced arthritis (CIA).

For research use only. We do not sell to patients.

Anti-Mouse TL1A/TNFSF15 Antibody (5G4.6)

Anti-Mouse TL1A/TNFSF15 Antibody (5G4.6) Chemical Structure

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Based on 1 publication(s) in Google Scholar

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Description

Anti-Mouse TL1A/TNFSF15 Antibody (5G4.6) is an anti-mouse TL1A/TNFSF15 IgG monoclonal antibody. Anti-Mouse TL1A/TNFSF15 Antibody (5G4.6) can reduce TL1A levels and block TL1A-DR3 interactions. Anti-Mouse TL1A/TNFSF15 Antibody (5G4.6) can be used for research on inflammation conditions such as colitis and collagen-induced arthritis (CIA)[1][2].

Isotype

Armenian hamster IgG
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target

TL1A/TNFSF15
In Vivo

Anti-Mouse TL1A/TNFSF15 Antibody (5G4.6) (20 mg/kg, i.p., on day -1 and 0) significantly alleviates the pathological manifestations and mortality rate of 2,4,6 trinitrobenzenesulfonic acid (TNBS) induced colitis in C57BL/10 mice[1].
Anti-Mouse TL1A/TNFSF15 Antibody (5G4.6) (20 mg/kg, i.p., once every 7 days, from day 21 to day 49) effectively reduces inflammation and bone destruction in male DBA/1 J mice with collagen-induced arthritis (CIA)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: TNBS induced colitis C57BL/10 mice [1]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection (i.p.), on day -1 and 0
Result: Significantly reduced TNBS induced weight loss.
Significantly reduced colitis score.
Significantly reduced inflammation infiltration and mucosal damage.
Might exert its effect by directly inhibiting effector T cell activation rather than regulating Tregs.
Animal Model: Chicken type II collagen (CII) (100 μg) induced male DBA/1 J mice (8-10 weeks)[2]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection (i.p.), once every 7 days from day 21 to day 49
Result: Significantly reduced bone erosion in mice.
Had no significant effect on systemic immunity.
Significantly reduced clinical scores.
Gene ID

326623  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse TL1A/TNFSF15 Antibody (5G4.6)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 95.00%

SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Anti-Mouse TL1A/TNFSF15 Antibody (5G4.6) Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse TL1A/TNFSF15 Antibody (5G4.6)TNF ReceptorTumor Necrosis Factor ReceptorTNFRTL1ATNFSF15colitisCIAInhibitorinhibitorinhibit

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Anti-Mouse TL1A/TNFSF15 Antibody (5G4.6)
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