2. Protein Tyrosine Kinase/RTK
  3. Insulin Receptor
  4. LAGIPRA peptide

LAGIPRA peptide is a long-acting GIP1R agonist. LAGIPRA peptide enhances insulin sensitivity by augmenting glucose disposal and reduces branched-chain amino acids (BCAAs) and ketoacids. LAGIPRA peptide has the potential for the research of type 2 diabetes.

For research use only. We do not sell to patients.

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LAGIPRA peptide

LAGIPRA peptide Chemical Structure

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LAGIPRA peptide Related Antibodies

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Description

LAGIPRA peptide is a long-acting GIP1R agonist. LAGIPRA peptide enhances insulin sensitivity by augmenting glucose disposal and reduces branched-chain amino acids (BCAAs) and ketoacids. LAGIPRA peptide has the potential for the research of type 2 diabetes[1].

In Vivo

LAGIPRA peptide (1000 nmol/kg; sc) reduces hyperglycemia in intraperitoneal glucose tolerance test experiments in Glp-1r–/– mice, but had no effect in Gipr-deficient (Gipr–/–) animals[1].
LAGIPRA peptide (300 nmol/kg; sc; once a day for 14 days) shows a small (4% reduction) effect on body weight and transient reduction (during the first 24-48 hours) in food intake, decreases fasting glucose and insulin[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male IR mice (onsisting of 60% fat, 20% carbohydrate, and 20% protein caloric content D12492; Research Diets)[1]
Dosage: 300 nmol/kg
Administration: SC; once a day for 14 days
Result: Showed a small (4% reduction) effect on body weight and transient reduction (during the first 24-48 hours) in food intake, decreases fasting glucose and insulin.
Molecular Weight

5756.50

Formula

C264H406N64O78S
Sequence

Tyr-{Aib}-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-{Lys(AEEA-AEEA-γGlu-C20 diacid)}-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-Gln
Sequence Shortening

Y-{Aib}-EGTFISDYSIAMDK-{Lys(AEEA-AEEA-γGlu-C20 diacid)}-HQQDFVNWLLAQKGKKNDWKHNITQ
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LAGIPRA peptide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LAGIPRA peptideLong acting GIPRA-1Long acting GIPRA1Long acting GIPRA 1Insulin Receptorbranched-chain amino acidstype 2 diabetesinsulinketoacidsInhibitorinhibitorinhibit

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