2. Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Epigenetics Cell Cycle/DNA Damage PI3K/Akt/mTOR
  3. Apoptosis Reactive Oxygen Species (ROS) PARP Caspase Akt
  4. Anticancer agent 277

Anticancer agent 277 (Compound 4a) is an anticancer agent. Anticancer agent 277 has cytotoxic activities against cancer cells. Anticancer agent 277 significantly inhibits hepatocellular carcinoma cells proliferation via arresting S and G2/M phase cell cycle and induces apoptosis by inducing ROS production and elevating apoptosis-related proteins expression. Anticancer agent 277 potently inhibits tumor growth in HepG2 xenograft mice model.

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Anticancer agent 277

Anticancer agent 277 Chemical Structure

CAS No. : 2673232-30-7

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Anticancer agent 277 Related Antibodies

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Description

Anticancer agent 277 (Compound 4a) is an anticancer agent. Anticancer agent 277 has cytotoxic activities against cancer cells. Anticancer agent 277 significantly inhibits hepatocellular carcinoma cells proliferation via arresting S and G2/M phase cell cycle and induces apoptosis by inducing ROS production and elevating apoptosis-related proteins expression. Anticancer agent 277 potently inhibits tumor growth in HepG2 xenograft mice model[1].

IC50 & Target[1]

Caspase 3

 

Molecular Weight

340.33

Formula

C18H16N2O5
CAS No.
SMILES

O=C1NC(C(C2=CC(OC)=C(OC)C(OC)=C2)=O)=NC3=CC=CC=C31
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Anticancer agent 277 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 2772673232-30-7Anticancer agent277Anticancer agent-277ApoptosisReactive Oxygen Species (ROS)PARPCaspaseAktpoly ADP ribose polymerase PKBProtein kinase BAnticancerCytotoxicHepG2 cellsBel-7402 cellsA549 cellsU251 cellsHepG2 xenograft mice modelInhibitorinhibitorinhibit

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