2. Stem Cell/Wnt
  3. Hippo (MST)
  4. MR24

MR24, a G-5555 (HY-19635) derivative, is a mammalian STE20-like (MST) kinase inhibitor. MR24 shows selectively to MST3/4 over MST1/2, with EC50 values of 57 and 583 nM, respectively. MR24 induces G1 phase cell cycle arrest. MR24 can be used for cancer research, such as breast, liver and lung cancers.

For research use only. We do not sell to patients.

MR24

MR24 Chemical Structure

CAS No. : 3056814-89-9

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

MR24 Related Antibodies

Top Publications Citing Use of Products

View All Hippo (MST) Isoform Specific Products:

View All Isoforms
MST1 MST2 MST3 MST4

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MR24, a G-5555 (HY-19635) derivative, is a mammalian STE20-like (MST) kinase inhibitor. MR24 shows selectively to MST3/4 over MST1/2, with EC50 values of 57 and 583 nM, respectively. MR24 induces G1 phase cell cycle arrest. MR24 can be used for cancer research, such as breast, liver and lung cancers[1].

IC50 & Target[1]

MST3

57 nM (EC50)

MST4

583 nM (EC50)

In Vitro

MR24 (compound 24) (1-10 μM, 6-72 h) shows no significant effect on cell healthy nuclei in HCT116 cells, and only results in a slight reduction in cell viability by about 30% at a concentration of 10 μM[1].
MR24 (1-10 μM, 24-72 h) induces G1 phase cell cycle arrest in HCT116 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MR24 Related Antibodies

Cell Cycle Analysis[1]

Cell Line: HCT116 cells
Concentration: 1, 5, and 10 μM
Incubation Time: 24, 48 and 72 h
Result: Increased the fraction of cells in the G1 phase at 10 μM.

Cell Viability Assay[1]

Cell Line: HCT116 cells
Concentration: 1 and 10 μM
Incubation Time: 6, 12, 24, 48 and 72 h
Result: Showed no significant effect on the normalized cell count at a concentration of 1 μM.
Resulted in a slight reduction in cell viability by about 30% at a concentration of 10 μM.
Resulted in over 90% healthy nuclei after 24 h at both concentrations used (1 and 10 μM).
Molecular Weight

509.00

Formula

C26H29ClN6O3
CAS No.
SMILES

CC1=CC=CC(C2=CC(Cl)=C(C=C2)C3=CC4=C(N(C3=O)CCCCN)N=C(N=C4)NC(CO)CO)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

MR24 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MR243056814-89-9MR 24MR-24Hippo (MST)MST3/4breast cancerliver cancerlung cancerHippoHCT116Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
MR24
Cat. No.:
HY-157932
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.