2. Stem Cell/Wnt
  3. Hippo (MST)
  4. MR24

MR24, a G-5555 (HY-19635) derivative, is a mammalian STE20-like (MST) kinase inhibitor. MR24 selectively target MST3/4, with EC50 values of 57 and 583 nM, respectively.

For research use only. We do not sell to patients.

MR24 Chemical Structure

MR24 Chemical Structure

CAS No. : 3056814-89-9

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MR24 Related Antibodies

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Description

MR24, a G-5555 (HY-19635) derivative, is a mammalian STE20-like (MST) kinase inhibitor. MR24 selectively target MST3/4, with EC50 values of 57 and 583 nM, respectively[1].

IC50 & Target

IC50: 57 ± 44 nM (MST3), 583 ± 210 nM (MST4)[1]
In Vitro

MR24 causes a cell-cycle arrest in the G1 phase[1].
MR24 exhibits an excellent microsomal stability of more than 90% over a time of 1 h[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MR24 Related Antibodies

Cell Cycle Analysis[1]

Cell Line: HCT116 cells
Concentration: 10 μM
Incubation Time: 24, 48, and 72 h
Result: Increased the fraction of cells in the G1 phase.
Molecular Weight

509.00

Formula

C26H29ClN6O3
CAS No.
SMILES

CC1=CC=CC(C2=CC(Cl)=C(C=C2)C3=CC4=C(N(C3=O)CCCCN)N=C(N=C4)NC(CO)CO)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MR24 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MR243056814-89-9MR 24MR-24Hippo (MST)HCT116 cellsmicrosomal stabilitymammalian STE20-like kinaseMSTInhibitorinhibitorinhibit

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