2. GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Dopamine Receptor Reactive Oxygen Species
  4. Dopamine D4 receptor ligand 3

Dopamine D4 receptor ligand 3 (Compound 16) is a dopamine D4 receptor (D4R) antagonist (pKi: 8.86). Dopamine D4 receptor ligand 3 has pIC50 values of 5.78, 5.55, and 6.17 for Go, Gi, and βArr2 sensors in HEK-293T cells, respectively. Dopamine D4 receptor ligand 3 inhibits the viability of three human glioma cell lines, U87 MG, T98G, and U251 MG. Dopamine D4 receptor ligand 3 induces ROS production and mitochondrial dysfunction in glioma cells.

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Dopamine D4 receptor ligand 3 Chemical Structure

Dopamine D4 receptor ligand 3 Chemical Structure

CAS No. : 3082344-46-2

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Dopamine D4 receptor ligand 3 Related Antibodies

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Description

Dopamine D4 receptor ligand 3 (Compound 16) is a dopamine D4 receptor (D4R) antagonist (pKi: 8.86). Dopamine D4 receptor ligand 3 has pIC50 values of 5.78, 5.55, and 6.17 for Go, Gi, and βArr2 sensors in HEK-293T cells, respectively. Dopamine D4 receptor ligand 3 inhibits the viability of three human glioma cell lines, U87 MG, T98G, and U251 MG. Dopamine D4 receptor ligand 3 induces ROS production and mitochondrial dysfunction in glioma cells[1].

Molecular Weight

489.56

Formula

C28H31N3O5
CAS No.
SMILES

O=C(CCC1=C2C=CC=C1)N2CCCN3CCN(CC3)C4=CC=C5C=CC=CC5=C4.O=C(O)C(O)=O
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Purity & Documentation
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Dopamine D4 receptor ligand 3 Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

Dopamine D4 receptor ligand 33082344-46-2Dopamine ReceptorReactive Oxygen SpeciesU87 MGT98GU251 MGglioma cellsHEK-293T cellsGoGiβArr2 sensorsanticancerInhibitorinhibitorinhibit

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