Pep2-SVKE 

Pep2-SVKE is an inactive control peptide for pep2-SVKI (HY-P1056). Pep2-SVKE is an inhibitory peptide corresponding to the last 10 amino acids of the C-terminus of the GluR2 AMPA receptor subunit. Pep2-SVKE does not block AMPA-mediated [³H]DA exocytosis. Pep2-SVKE does not bind to GRIP or PICK43 and does not block retention of PICK1 by GST-GluR2 and LTD^{[1][2][3][4][5]}.

Pep2-SVKE (100 μM) does not block mGluR-LTD in dopaminergic (DA) neurons^[1].

Pep2-SVKE (1 mM) does not bind to PICK or GRIP46, nor does it inhibit the increase in EPSC amplitude ratio (R+40/-60mV) induced by active peptides^[2].

Pep2-SVKE (1 mM) does not bind to GRIP or PICK43, nor does it alter mEPSC amplitude and AMPA- and NMDA-induced [³H]ACh release at somatic AMPAR receptors^[2][4].

Pep2-SVKE (1 μM) does not alter the dramatic reduction in [³H]DA efflux^[3].

Pep2-SVKE does not abolish AMPA receptor sensitivity to cyclothiazide, which controls the release of [³H] nucleoside analogs (NA)^[4].

Pep2-SVKE (133 μM) does not block the retention of PICK1 by GST-GluR2 and LTD^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1300.41

C₅₉H₈₉N₁₃O₂₀

1315378-76-7

Tyr-Asn-Val-Tyr-Gly-Ile-Glu-Ser-Val-Lys-Glu

YNVYGIESVKE

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mameli M, et al. Rapid synthesis and synaptic insertion of GluR2 for mGluR-LTD in the ventral tegmental area. Science. 2007 Jul 27;317(5837):530-3.  [Content Brief]

  [2]. Liu SJ, et al. Subunit interaction with PICK and GRIP controls Ca2+ permeability of AMPARs at cerebellar synapses. Nat Neurosci. 2005 Jun;8(6):768-75.  [Content Brief]

  [3]. Grilli M, et al. In vitro exposure to nicotine induces endocytosis of presynaptic AMPA receptors modulating dopamine release in rat nucleus accumbens nerve terminals. Neuropharmacology. 2012 Oct;63(5):916-26.  [Content Brief]

  [4]. Pittaluga A, et al. Trafficking of presynaptic AMPA receptors mediating neurotransmitter release: neuronal selectivity and relationships with sensitivity to cyclothiazide. Neuropharmacology. 2006 Mar;50(3):286-96.  [Content Brief]

  [5]. Daw MI, et al. PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses. Neuron. 2000 Dec;28(3):873-86.  [Content Brief]