2. JAK/STAT Signaling Stem Cell/Wnt Apoptosis Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Cell Cycle/DNA Damage Epigenetics
  3. STAT Apoptosis Reactive Oxygen Species (ROS) PARP
  4. KB-15

KB-15 is a STAT3 inhibitor. KB-15 exhibits potent anti-proliferative activity against AGS gastric cancer cells (IC50 = 0.29 μM) and BGC-823 gastric cancer cells (IC50 = 0.65 μM). KB-15 exerts anti-tumor effects by inhibiting STAT3 phosphorylation, downregulating HO-1 expression, and promoting intracellular ROS accumulation. KB-15 induces G0/G1 phase cell cycle arrest and apoptosis, as well as suppresses colony formation and migration of gastric cancer cells. KB-15 demonstrates excellent anti-tumor efficacy in BGC-823 subcutaneous xenograft model. KB-15 can be used for the study of gastric cancer.

For research use only. We do not sell to patients.

KB-15

KB-15 Chemical Structure

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KB-15 Related Antibodies

Top Publications Citing Use of Products

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STAT3 STAT5 STAT6 STAT1

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Description

KB-15 is a STAT3 inhibitor. KB-15 exhibits potent anti-proliferative activity against AGS gastric cancer cells (IC50 = 0.29 μM) and BGC-823 gastric cancer cells (IC50 = 0.65 μM). KB-15 exerts anti-tumor effects by inhibiting STAT3 phosphorylation, downregulating HO-1 expression, and promoting intracellular ROS accumulation. KB-15 induces G0/G1 phase cell cycle arrest and apoptosis, as well as suppresses colony formation and migration of gastric cancer cells. KB-15 demonstrates excellent anti-tumor efficacy in BGC-823 subcutaneous xenograft model. KB-15 can be used for the study of gastric cancer[1].
In Vitro

KB-15 (72 h) exhibits potent anti-proliferative activity against AGS gastric cancer cells (IC50 = 0.29 μM) and BGC-823 gastric cancer cells (IC50 = 0.65 μM)[1].
KB-15 (0.25-2 μM, 14 days) shows potent colony formation inhibitory activity against AGS and BGC-823 gastric cancer cells[1].
KB-15 (0.5-2 μM, 24 h) demonstrates potent ROS-inducing activity in BGC-823 cells[1].
KB-15 (0.25-2 μM, 24-36 h) exhibits potent G0/G1 phase arrest activity and induces apoptosis in AGS and BGC-823 cells[1].
KB-15 (0.5-2 μM, 24 h) inhibits STAT3 activation in a concentration-dependent manner and downregulates HO-1 in BGC-823 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KB-15 Related Antibodies

Cell Cycle Analysis[1]

Cell Line: AGS and BGC-823 cells
Concentration: 0.25, 0.5, 1, 2 μM
Incubation Time: 36 h
Result: Induced concentration-dependent increase in the proportion of G0/G1 phase cells.

Apoptosis Analysis[1]

Cell Line: BGC-823 cells
Concentration: 0.5, 1, 2 μM
Incubation Time: 24 h
Result: Increased the total apoptosis rate in a concentration-dependent manner.
Upregulated pro-apoptotic proteins Cleaved-PARP and Bax.

Western Blot Analysis[1]

Cell Line: BGC-823 cells
Concentration: 0.5, 1, 2 μM
Incubation Time: 24 h
Result: Inhibited STAT3 activation in a concentration-dependent manner and downregulated HO-1.
In Vivo

KB-15 (2.5 mg/kg, i.p., once daily, 14 consecutive days) demonstrates excellent anti-tumor efficacy in BGC-823 subcutaneous xenograft model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BGC-823 cells (5 × 107 in serum-free medium) were subcutaneously implanted into the left axillary area of 6-week-old male BALB/c (nu/nu) nude mice[1]
Dosage: 2.5 mg/kg
Administration: i.p. once daily for 14 consecutive days
Result: Achieved a tumor growth inhibition (TGI) rate of 53.3% at a dose of 2.5 mg/kg.
Reduced the expression of phosphorylated STAT3 (p-STAT3) and HO-1 protein in BGC-823 xenograft tumor tissues.
Increased the expression of pro-apoptotic proteins Cleaved-PARP and Bax, and decreased the expression of apoptotic protease Procaspase-3 in tumor tissues.
Molecular Weight

430.11

Formula

C18H12Cl4N2O2
SMILES

ClC1=C(Cl)C=CC(/C=C/C(NNC(/C=C/C2=CC(Cl)=C(Cl)C=C2)=O)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KB-15 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KB-15KB15KB 15STATApoptosisReactive Oxygen Species (ROS)PARPpoly ADP ribose polymerasegastric cancerBGC-823AGS gastric cancer cellsROSapoptosisInhibitorinhibitorinhibit

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