10-Methoxy-canthin-6-one (Synonyms: Mtx-C)

Name: 10-Methoxy-canthin-6-one
Brand: MedChemExpress
SKU: HY-169067
Rating: 4.5 (1 reviews)

Cat. No.: HY-169067 Purity: 98.71%: Data Sheet
COA

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Handling Instructions
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10-Methoxy-canthin-6-one (Mtx-C) is analkaloid derivative. 10-Methoxy-canthin-6-one can induce DNA damage by intercalating into DNA. 10-Methoxy-canthin-6-one can inhibit cancer cells proliferation, cause G2/M phase arrest and induce myeloid differentiation. T10-Methoxy-canthin-6-one can upregulate the expression of myeloperoxidase, CD15, CD11b, and CD14, as well as activation of p38 MAPK. 10-Methoxy-canthin-6-one also exhibits anti-bacterial activity. 10-Methoxy-canthin-6-one can be used for the researches of cancer and infection, such as acute myeloid leukemias (AML).

For research use only. We do not sell to patients.

10-Methoxy-canthin-6-one Chemical Structure

CAS No. : 86293-40-5

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

Biological Activity
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	1.58 μg/mL Compound: 43	Antiproliferative activity against human DU-145 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human DU-145 cells incubated for 48 hrs by MTT assay	[PMID: 34332400]
HCC1395	IC₅₀	14.7 μg/mL Compound: 43	Antiproliferative activity against human HCC1395 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human HCC1395 cells incubated for 48 hrs by MTT assay	[PMID: 34332400]

In Vitro

10-Methoxy-canthin-6-one (0.9-15 μM, 72 h) inhibits the proliferation of AML cell lines Kasumi-1 and KG-1. With with EC₅₀ values of 5.1 μM and 6.0 μM^[1].
10-Methoxy-canthin-6-one (2-4 μM, 72 h) induces G2/M phase cell cycle arrest in Kasumi-1 and KG-1 cells^[1].
10-Methoxy-canthin-6-one (2-4 μM, 72 h) inhibits colony formation of KG-1 cells^[1].
10-Methoxy-canthin-6-one (2-4 μM, 72 h) upregulates phosphorylation of DNA damage response proteins (ATR, Chk1, Chk2, p53, H2A.X) in Kasumi-1 and KG-1 cells^[1].
10-Methoxy-canthin-6-one (2-4 μM, 72 h) induces myeloid differentiation in Kasumi-1 and KG-1 cells^[1].
10-Methoxycanthin-6-one (12-14 h) inhibits Bacillus cereus, Ralstonia solanacearum and Pseudomonas syringae with MIC values of 3.91, 15.63 and 7.81 μg/mL^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:	Kasumi-1 and KG-1 cells
Concentration:	2 and 4 μM
Incubation Time:	72 h
Result:	Increased G2/M phase cell accumulation. Upregulated cyclin B1 phosphorylation and cyclin-dependent kinase inhibitors (p16, p21, p27). Reduced Ki-67 expression and increased retinoblastoma protein (Rb) phosphorylatio.

Cell Differentiation Assay^[1]

Cell Line:	Kasumi-1 and KG-1 cells
Concentration:	2 and 4 μM
Incubation Time:	72 h
Result:	Increased expression of myeloid markers (PU.1, myeloperoxidase/MPO, CD15, CD11b, CD14). Increased p38 MAPK phosphorylation.

Molecular Weight

250.25

Formula

C₁₅H₁₀N₂O₂

CAS No.

86293-40-5

Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=C1C=CC2=NC=CC3=C2N1C4=CC=C(OC)C=C34

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 3.33 mg/mL (13.31 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.9960 mL	19.9800 mL	39.9600 mL
5 mM	0.7992 mL	3.9960 mL	7.9920 mL
10 mM	0.3996 mL	1.9980 mL	3.9960 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.71%

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Data Sheet (280 KB) SDS (252 KB)

COA (257 KB) HNMR (244 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Torquato HFV, et al. DNA Damage-Inducing 10-Methoxy-canthin-6-one (Mtx-C) Promotes Cell Cycle Arrest in G2/M and Myeloid Differentiation of Acute Myeloid Leukemias and Leukemic Stem Cells. ACS Omega. 2024 Aug 22;9(35):37343-37354. [Content Brief]

[2]. Li N, et al. Synthesis and In Vitro Antibacterial Activity of Quaternized 10-Methoxycanthin-6-one Derivatives. Molecules. 2019 Apr 19;24(8):1553. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.9960 mL	19.9800 mL	39.9600 mL	99.9001 mL
	5 mM	0.7992 mL	3.9960 mL	7.9920 mL	19.9800 mL
	10 mM	0.3996 mL	1.9980 mL	3.9960 mL	9.9900 mL

10-Methoxy-canthin-6-one Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

10-Methoxy-canthin-6-one86293-40-5Mtx-CDNA/RNA Synthesisp38 MAPKBacterialDNAG2/M phaseMyeloid differentiationCD15CD11bCD14Acute myeloid leukemiasBacillus cereusInhibitorinhibitorinhibit

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10-Methoxy-canthin-6-one (Synonyms: Mtx-C)

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10-Methoxy-canthin-6-one Related Antibodies

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References

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10-Methoxy-canthin-6-one Related Antibodies

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Complete Stock Solution Preparation Table

10-Methoxy-canthin-6-one Related Classifications

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