VSLRGDTRG acetate

Cat. No.: HY-P10941A: FAQs
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VSLRGDTRG acetate is a synthetic peptide containing the RGD motif from cadherin 17 (CDH17), which binds to α2β1 integrin and activates its signaling pathway. VSLRGDTRG acetate promotes the high-affinity conformational change of β1 integrin through the RGD motif, enhancing cell adhesion and phosphorylation of FAK and ERK1/2, thereby driving tumor proliferation and metastasis. VSLRGDTRG acetate can be used in research on cancers expressing CDH17, such as colon cancer and pancreatic cancer.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

VSLRGDTRG acetate Chemical Structure

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Other Forms of VSLRGDTRG acetate:

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•Related Small Molecules:

•Related Proteins:

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

View All ERK Isoform Specific Products:

View All Isoforms

ERK ERK1 ERK2 ERK5 ERK8

Biological Activity
Purity & Documentation
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Description	VSLRGDTRG acetate is a synthetic peptide containing the RGD motif from cadherin 17 (CDH17), which binds to α2β1 integrin and activates its signaling pathway. VSLRGDTRG acetate promotes the high-affinity conformational change of β1 integrin through the RGD motif, enhancing cell adhesion and phosphorylation of FAK and ERK1/2, thereby driving tumor proliferation and metastasis. VSLRGDTRG acetate can be used in research on cancers expressing CDH17, such as colon cancer and pancreatic cancer^[1]^[2].
Molecular Weight	960.05 (free base)
Formula	C₃₈H₆₉N₁₅O₁₄.xC₂H₄O₂
Sequence	Val-Ser-Leu-Arg-Gly-Asp-Thr-Arg-Gly
Sequence Shortening	VSLRGDTRG
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (269 KB) Handling Instructions (2659 KB)
References	[1]. Bartolome R A, et al. An RGD motif present in cadherin 17 induces integrin activation and tumor growth[J]. Journal of Biological Chemistry, 2014, 289(50): 34801-34814. [2]. Jose Ignacio CASAL ALVAREZ, et al. Agents binding specifically to human cadherin-17, human cadherin-5, human cadherin-6 and human cadherin-20 rgd motif. Patent, WO2016169581A1, 2016-10-27.