SOP1812 (Synonyms: QN-302)

Name: SOP1812
Brand: MedChemExpress
SKU: HY-148012
Rating: 4.5 (1 reviews)

Cat. No.: HY-148012 Purity: 98.46%: Data Sheet
COA

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Handling Instructions
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SOP1812 (QN-302) is a naphthalene diimide (ND) derivative with anti-tumor activity. SOP1812 binds to quadruplex arrangements (G4s), and down-regulates several cancer gene pathways. SOP1812 shows great affinity to hTERT G4 and HuTel21 G4 with K_D values of 4.9 and 28.4 nM, respectively. SOP1812 can be used for the research of cancer.

For research use only. We do not sell to patients.

SOP1812 Chemical Structure

CAS No. : 2546091-70-5

Size	Stock	Quantity
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
BXPC-3	GI₅₀	2.6 nM Compound: 11; SOP1812	Antiproliferative activity against human BxPC3 cells assessed as growth inhibition after 96 hrs by SRB assay Antiproliferative activity against human BxPC3 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 32832034]
CAPAN-1	GI₅₀	5.9 nM Compound: 11; SOP1812	Antiproliferative activity against human Capan1 cells assessed as growth inhibition after 96 hrs by SRB assay Antiproliferative activity against human Capan1 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 32832034]
MIA PaCa-2	GI₅₀	1.3 nM Compound: 11; SOP1812	Antiproliferative activity against human MIAPaCa2 cells assessed as growth inhibition after 96 hrs by SRB assay Antiproliferative activity against human MIAPaCa2 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 32832034]
PANC-1	GI₅₀	1.4 nM Compound: 11; SOP1812	Antiproliferative activity against human PANC1 cells assessed as growth inhibition after 96 hrs by SRB assay Antiproliferative activity against human PANC1 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 32832034]

In Vitro

SOP1812 (0-50 nM; 96 h) inhibits the proliferation of many cancer cells^[1].
SOP1812 (0-800 nM; 6-24 h) shows great affinity to hTERT G4 and HuTel21 G4^[1].
SOP1812 (40 nM; 6-24 h) affects Wnt/β-catenin, axon guidance, Hippo, MAPK and Rap1 pathways^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	MIA PaCa-2, PANC-1, Capan-1 and BxPC-3 cell lines
Concentration:	0-50 nM
Incubation Time:	96 hours
Result:	Showed anti-proliferation ability to MIA PaCa-2, PANC-1, Capan-1 and BxPC-3 cells with GI₅₀ values of 1.3, 1.4, 5.9 and 2.6 nM, respectively.

Cell Viability Assay^[1]

Cell Line:	PANC-1 cells
Concentration:	0, 100, 400 and 800 nM
Incubation Time:	6 and 24 hours
Result:	Binded to hTERT G4 and HuTel21 G4 with K_D values of 4.9 and 28.4 nM, respectively.

Cell Viability Assay^[1]

Cell Line:	MIA PaCa-2 Cells
Concentration:	40 nM
Incubation Time:	6 and 24 hours
Result:	Affected WNT5B, DVL1, AXIN and APC2 expression which includes in Wnt/β-catenin pathway and also showed effects on axon guidance, Hippo, MAPK, and Rap1 pathways.

In Vivo

SOP1812 (1 mg/kg; i.v. once or twice per week for 28 days) shows anti-tumor activity in MIA PaCa-2 xenografts mice and KPC mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female athymic nude mice with MIA PaCa-2 xenografts^[1]
Dosage:	1 mg/kg
Administration:	Intravenous injection; 1 mg/kg once or twice per week; for 28 days
Result:	Showed complete tumor regression and no significant tumor regrowth after day 28 on several animals.

Animal Model:	KPC mice with PDAC symptoms^[1]
Dosage:	1 mg/kg
Administration:	Intravenous injection; 1 mg/kg once per week; for 3 weeks
Result:	Significantly extended survival of KPC mice and showed a better effect than gemcitabine.

Clinical Trial

Molecular Weight

791.98

Formula

C₄₅H₅₇N₇O₆

CAS No.

2546091-70-5

Appearance

Solid

Color

Brown to reddish brown

SMILES

O=C1C2=CC(NCCN3CCCC3)=C4C(N(CCCN5CCOCC5)C(C6=CC(C7=CC=C(CN8CCCC8)C=C7)=C(C2=C64)C(N1CCCN9CCOCC9)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: 98.46%

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Data Sheet (287 KB) SDS (393 KB)

COA (252 KB) HNMR (253 KB) RP-HPLC (252 KB) MS (177 KB)

Handling Instructions (2659 KB)

References

[1]. Ahmed AA, et al. Asymmetrically Substituted Quadruplex-Binding Naphthalene Diimide Showing Potent Activity in Pancreatic Cancer Models. ACS Med Chem Lett. 2020 Jul 16;11(8):1634-1644. [Content Brief]

SOP1812 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SOP18122546091-70-5QN-302SOP 1812SOP-1812QN302QN 302G-quadruplexNDquadruplexMIA PaCa-2G4Wnt/β-cateninPANC-1BxPC-3PDACInhibitorinhibitorinhibit

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SOP1812 (Synonyms: QN-302)

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