2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Metabolic Enzyme/Protease Apoptosis
  3. EGFR Carbonic Anhydrase Caspase
  4. EGFR/CA-IX-IN-1

EGFR/CA-IX-IN-1 (Compound 14) is a dual inhibitor against epidermal growth factor receptor (EGFR) and carbonic anhydrase IX (CA-IX) with IC50 values of 5.92 nM and 63 nM, respectively. EGFR/CA-IX-IN-1 shows strong cytotoxicity against breast cancer cells (MDA-MB-231, MCF-7) with IC50 values of 5.78 μM and 8.05 μM, respectively. EGFR/CA-IX-IN-1 inhibits the catalytic activity of CA-IX, up-regulates BAX/Bcl-2, activates caspases, and arrests the cell cycle at the G1 phase. EGFR/CA-IX-IN-1 is promising for research of breast cancer.

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EGFR/CA-IX-IN-1 Chemical Structure

EGFR/CA-IX-IN-1 Chemical Structure

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EGFR/CA-IX-IN-1 Related Antibodies

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

View All Carbonic Anhydrase Isoform Specific Products:

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CA CA I CA Ⅱ CA IX CA XII

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Description

EGFR/CA-IX-IN-1 (Compound 14) is a dual inhibitor against epidermal growth factor receptor (EGFR) and carbonic anhydrase IX (CA-IX) with IC50 values of 5.92 nM and 63 nM, respectively. EGFR/CA-IX-IN-1 shows strong cytotoxicity against breast cancer cells (MDA-MB-231, MCF-7) with IC50 values of 5.78 μM and 8.05 μM, respectively. EGFR/CA-IX-IN-1 inhibits the catalytic activity of CA-IX, up-regulates BAX/Bcl-2, activates caspases, and arrests the cell cycle at the G1 phase. EGFR/CA-IX-IN-1 is promising for research of breast cancer[1].

IC50 & Target

CA IX

63 nM (IC50)

Molecular Weight

472.54

Formula

C20H20N6O4S2
SMILES

NS(C1=CC=C(N2N=C(C(C)=O)S/C2=N\N=C(C)/C3=CC=C(NC(C)=O)C=C3)C=C1)(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EGFR/CA-IX-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR/CA-IX-IN-1EGFRCarbonic AnhydraseCaspaseEpidermal growth factor receptorErbB-1HER1Carbonate dehydrataseCA-IXMDA-MB-231MCF-7breast cancerInhibitorinhibitorinhibit

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EGFR/CA-IX-IN-1
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