2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Topoisomerase II inhibitor 6

Topoisomerase II inhibitor 6 (Compound 5), a tryptanthrin derivative, is a potent and selective inhibitor of topoisomerase II. Topoisomerase II inhibitor 6 exhibits antiproliferative activity on different tumor cell lines. Topoisomerase II inhibitor 6 blocks the cell cycle of CCRF-CEM in the G2 phase and induces DNA DSB. Topoisomerase II inhibitor 6 has the potential for the research of cancer diseases.

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Topoisomerase II inhibitor 6

Topoisomerase II inhibitor 6 Chemical Structure

CAS No. : 2987586-62-7

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Description

Topoisomerase II inhibitor 6 (Compound 5), a tryptanthrin derivative, is a potent and selective inhibitor of topoisomerase II. Topoisomerase II inhibitor 6 exhibits antiproliferative activity on different tumor cell lines. Topoisomerase II inhibitor 6 blocks the cell cycle of CCRF-CEM in the G2 phase and induces DNA DSB. Topoisomerase II inhibitor 6 has the potential for the research of cancer diseases[1].

Cellular Effect
Cell Line Type Value Description References
CCRF-CEM GI50
1.36 μM
Compound: 5
Antiproliferative activity against human CCRF-CEM cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method
Antiproliferative activity against human CCRF-CEM cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method
[PMID: 32712536]
CCRF-CEM IC50
8.26 μM
Compound: 5
Antiproliferative activity against human CCRF-CEM cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method
Antiproliferative activity against human CCRF-CEM cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method
[PMID: 32712536]
CEM/C2 IC50
9.16 μM
Compound: 5
Antiproliferative activity against human CEM/C2 cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method
Antiproliferative activity against human CEM/C2 cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method
[PMID: 32712536]
DLD-1 IC50
7.13 μM
Compound: 5
Antiproliferative activity against human DLD-1 cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method
Antiproliferative activity against human DLD-1 cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method
[PMID: 32712536]
HL-60 IC50
11.46 μM
Compound: 5
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method
[PMID: 32712536]
HT-29 IC50
9.4 μM
Compound: 5
Antiproliferative activity against human HT29 cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method
Antiproliferative activity against human HT29 cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method
[PMID: 32712536]
Jurkat IC50
18.2 μM
Compound: 5
Antiproliferative activity against human Jurkat cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method
Antiproliferative activity against human Jurkat cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method
[PMID: 32712536]
MCF7 IC50
30.48 μM
Compound: 5
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method
[PMID: 32712536]
Molecular Weight

334.37

Formula

C19H18N4O2
CAS No.
SMILES

O=C1C2=NC3=C(C(N2C4=C1C(NCCN(C)C)=CC=C4)=O)C=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Topoisomerase II inhibitor 6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topoisomerase II inhibitor 62987586-62-7Topoisomerase II inhibitor6Topoisomerase II inhibitor-6Topoisomerasetryptanthrin derivativeTopoisomerase IIantiproliferativecell cycleG2 phaseDNA DSBcancerInhibitorinhibitorinhibit

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