2. Apoptosis Cell Cycle/DNA Damage
  3. Apoptosis DNA/RNA Synthesis
  4. Morindone

Morindone is an anthraquinone found in Morinda citrifolia L. Morindone can inhibit cancer cells proliferation, induce apoptosis and cause G1 phase arrest. Morindone can inhibit activities of DNA polymerase and downregulate mutated TP53 and KRAS gene expression. Morindone can be used for the research of cancer, such as colon cancer.

For research use only. We do not sell to patients.

Morindone

Morindone Chemical Structure

CAS No. : 478-29-5

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Morindone Related Antibodies

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Description

Morindone is an anthraquinone found in Morinda citrifolia L. Morindone can inhibit cancer cells proliferation, induce apoptosis and cause G1 phase arrest. Morindone can inhibit activities of DNA polymerase and downregulate mutated TP53 and KRAS gene expression. Morindone can be used for the research of cancer, such as colon cancer[1][2].

In Vitro

Morindone (0.39-50 μM, 24-72 h) inhibits the proliferation of KRAS-mutant HCT116 and TP53-mutant HT29 colorectal cancer cells[1].
Morindone (10.7-19.2 μM, 72 h) induces apoptosis in HCT116 and HT29 cells[1].
Morindone (10.7-19.2 μM, 24-72 h) induces G1 phase arrest in HCT116 and HT29 cells[1].
Morindone (10.7-19.2 μM, 72 h) downregulates mutated KRAS, BRAF, and mutated PIK3CA in HCT116 cells, and downregulates mutated TP53 and BAX, while upregulates p21 in HT29 cells[1].
Morindone (28.1-35.9 μM, 60 mins) inhibits the activities of animal A-family, B-family and Y-family DNA polymerases with IC50 values of 28.1-35.9 μM[2].
Morindone (24 h) inhibits the proliferation of human colon cancer HCT116 cells with an LD50of 32.2 μM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Morindone Related Antibodies

Cell Proliferation Assay[1]

Cell Line: KRAS-mutant HCT116 and TP53-mutant HT29 colorectal cancer cells
Concentration: 0.39, 0.78, 1.56, 3.12, 6.25, 12.5, 25 and 50 μM
Incubation Time: 24, 48 and 72 h
Result: Showed 3.06% proliferation inhibition in HCT116 cells at 3.12 μM for 24 h and complete proliferation inhibition at 50 μM for 72 h.
Exhibited 20.5% inhibition at 0.78 μM for 24 h and over 90% inhibition at 12.5-50 μM for 72 h in HT29 cells.

Western Blot Analysis[1]

Cell Line: HCT116 and HT29 cells
Concentration: 10.7 μM for HCT116, 19.2 μM for HT29
Incubation Time: 72 h
Result: Downregulated mutated KRAS, BRAF, and mutated PIK3CA in HCT116 cells.
Downregulated mutated TP53 and BAX, while upregulates p21 in HT29 cells.
Molecular Weight

270.24

Formula

C15H10O5
CAS No.
SMILES

O=C1C2=CC=C(C)C(O)=C2C(C3=CC=C(C(O)=C13)O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Morindone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Morindone478-29-5ApoptosisDNA/RNA SynthesisMorinda citrifolia LAnthraquinoneDNA polymeraseTP53KRASColon cancerInhibitorinhibitorinhibit

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