Anti-Mouse IL-18 Antibody (YIGIF74-1G7)

Cat. No.: HY-P990220: Data Sheet
FAQs
Technical Support

Anti-Mouse IL-18 Antibody (YIGIF74-1G7) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse IL-18. Anti-Mouse IL-18 Antibody (YIGIF74-1G7) can neutralize IL-18. Anti-Mouse IL-18 Antibody (YIGIF74-1G7) can be used for the researches of cancer, infection, inflammation and immunology, such as hepatocellular carcinoma and eosinophilic esophagitis.

For research use only. We do not sell to patients.

Anti-Mouse IL-18 Antibody (YIGIF74-1G7) Chemical Structure

Size		Stock
MOQ		Minimum order quantity
1 mg		Get quote
5 mg		Get quote
10 mg		Get quote
Other size		Get quote

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Anti-Mouse IL-18 Antibody (YIGIF74-1G7) Featured Recommendations:

1 Publications Citing Use of MCE Anti-Mouse IL-18 Antibody (YIGIF74-1G7)

•Crit Rev Eukaryot Gene Expr. 2024;34(8):35-45. [Abstract]

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Interleukin Related Isoform Specific Products:

View All Isoforms

IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

Biological Activity
Purity & Documentation
References
Customer Review

Description

Isotype

Rat IgG2a kappa

Recommend Isotype Controls

Rat IgG2a kappa, Isotype Control

Species Reactivity

Mouse

IC₅₀ & Target

IL-18

In Vitro

Anti-Mouse IL-18 Antibody (YIGIF74-1G7) (5 μg/mL) neutralizes IL-18 in dendritic cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-Mouse IL-18 Antibody (YIGIF74-1G7) (200 μg for the first time and 100 μg once a week, i.p.) shows anti-tumor effect in hepatocellular carcinoma mice models^[1].
Anti-Mouse IL-18 Antibody (YIGIF74-1G7) (200 μg, 3 times before infection) strongly reduces the protective effects of the T.mu-colonization in Salmonella-infected mice^[2].
Anti-Mouse IL-18 Antibody (YIGIF74-1G7) (200 μg, i.p., twice a week for 3 weeks) shows anti-inflammation effect in eosinophilic esophagitis mice models^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Hepatocellular carcinoma mice models^[1]
Dosage:	200 μg for the first time and 100 μg once a week
Administration:	Intraperitoneally injection
Result:	Increased IFNγ and decreased IL-6, TNFα, IL-1β, CCL2, CXCL1.

Gene ID

16173 [NCBI]

Accession

P70380

Application

ELISA, FACS, Functional assay, Research in vivo

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

150 kDa

SMILES

[Anti-Mouse IL-18 Antibody (YIGIF74-1G7)]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Inhibitory Antibodies User Guide (602 KB)

References

[1]. Goulet DR, Atkins WM. Considerations for the Design of Antibody-Based Therapeutics. J Pharm Sci. 2020 Jan;109(1):74-103. [Content Brief]

[2]. Molgora M, et al. IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity. Nature. 2017 Nov 2;551(7678):110-114. [Content Brief]

[3]. Chudnovskiy A, et al. Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome. Cell. 2016 Oct 6;167(2):444-456.e14. [Content Brief]

[4]. Yadavalli CS, et al. Allergen-induced NLRP3/caspase1/IL-18 signaling initiate eosinophilic esophagitis and respective inhibitors protect disease pathogenesis. Commun Biol. 2023 Jul 31;6(1):763. [Content Brief]

Anti-Mouse IL-18 Antibody (YIGIF74-1G7) Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IL-18 Antibody (YIGIF74-1G7)Interleukin RelatedILIL-18Hepatocellular carcinomaEosinophilic esophagitisSalmonellaInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *