2. Anti-infection Metabolic Enzyme/Protease
  3. Fungal Cytochrome P450
  4. CYP51-IN-26

CYP51-IN-26 is a CYP51 inhibitor with an IC50 value of approximately 0.40 μM. CYP51-IN-26 eradicates C. auris biofilms. CYP51-IN-26 demonstrates significantly improved intracellular uptake in an accumulation assay. CYP51-IN-26 protects against C. auris infection in both G. mellonella and D. melanogaster models. CYP51-IN-26 can be used for research on fungal infections.

For research use only. We do not sell to patients.

CYP51-IN-26 Chemical Structure

CYP51-IN-26 Chemical Structure

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CYP51-IN-26 Related Antibodies

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View All Cytochrome P450 Isoform Specific Products:

View All Isoforms
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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Description

CYP51-IN-26 is a CYP51 inhibitor with an IC50 value of approximately 0.40 μM. CYP51-IN-26 eradicates C. auris biofilms. CYP51-IN-26 demonstrates significantly improved intracellular uptake in an accumulation assay. CYP51-IN-26 protects against C. auris infection in both G. mellonella and D. melanogaster models. CYP51-IN-26 can be used for research on fungal infections[1].

In Vitro

CYP51-IN-26 (Compound 7) accumulates to significantly higher levels than Fluconazole (HY-B0101) in C. auris strain TDG1912[1].
CYP51-IN-26 shows antifungal activity to C.albicans NCNCPF3281(0.125 μg/mL), N.glabratus NCPF8018 (0.25 μg/mL), C.tropicalis NCPF8760 (0.25 μg/mL), C.parapsilosis NCPF3209 (0.125 μg/mL), TDG19 12 (0.25 μg/mL), TDG25 12 (0.06 μg/mL), TDG11 02 (4 μg/mL), TDG22 11 (0.5 μg/mL), TDG25 06 (≤ 0.03 μg/mL), NCPF89 84 (≤ 0.03 μg/mL), NCPF8971 (≤ 0.25 μg/mL) and NCPF8977 (≤ 0.03 μg/mL)[1].
CYP51-IN-26 (0.03-64 μg/mL, 24 h) significantly reduces biofilm biomass, exhibiting eradication activity comparable to Voriconazole (HY-76200)[1].
CYP51-IN-26 (0-25 h) demonstrates inhibition of C. auris TDG1912 growth for at least 6 hours of incubation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CYP51-IN-26 Related Antibodies
In Vivo

CYP51-IN-26 (Compound 7) (10-50 mg/kg, local injection, once after infection 30 min) demonstrates significant antifungal efficacy in a G. mellonella model infected with C. auris (TDG1912)[1].
CYP51-IN-26 (5-50 mg/kg, local injection, once after infection 1 h) improves survival in Drosophila melanogaster infection model challenged with C. auris[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: G. mellonella larvae were injected with 10 μL of C.auris strain TDG1912 at 1 × 107 CFU/mL into the first left proleg[1]
Dosage: 10, 20, 50 mg/kg
Administration: Local injected once after infection 30 min
Result: Demonstrated significant antifungal efficacy at 50 mg/kg and 20 mg/kg doses.
Animal Model: D.melaogaster adults were injected with 10 nL of C.auris strain TDG1912 at a concentration of 2 × 1011 CFU/mL or 1 × 1012 CFU/mL into the dorsolateral thorax below the right wing hinge[1]
Dosage: 5, 20, 50 mg/kg
Administration: Local injected once after infection 1 h
Result: Improved survival at both 50 and 20 mg/kg compared to the untreated group.
Molecular Weight

433.43

Formula

C20H22F3N7O
SMILES

OC(C1=CC=C(C=C1F)F)(CN2CCC(CC2)NC3=NC=C(C=N3)F)CN4N=CN=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CYP51-IN-26 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CYP51-IN-26FungalCytochrome P450CYPsCYP51fungal infectionG. mellonellaD. melanogasterC. aurisInhibitorinhibitorinhibit

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