2. PROTAC Protein Tyrosine Kinase/RTK Apoptosis JAK/STAT Signaling Stem Cell/Wnt
  3. PROTACs c-Met/HGFR Apoptosis STAT
  4. PROTAC c-Met degrader-5

PROTAC c-Met degrader-5 (Compound D19) is an orally active c-Met PROTAC degrader with DC50s of 0.42 and 0.32 nM in EBC-1 and Hs746T cells, respectively. PROTAC c-Met degrader-5 significantly induces cell apoptosis, G1 cell cycle arrest, and inhibits cell migration and invasion. PROTAC c-Met degrader-5 has potent antiproliferative and degradation efficacy against c-Met-addicted cancer cells and Tepotinib (HY-14721)-resistant cancer cells. Pink: c-Met ligand (HY-W425461); Blue: CRBN ligase ligand (HY-14658); Black: linker

For research use only. We do not sell to patients.

PROTAC c-Met degrader-5

PROTAC c-Met degrader-5 Chemical Structure

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PROTAC c-Met degrader-5 Related Antibodies

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Description

PROTAC c-Met degrader-5 (Compound D19) is an orally active c-Met PROTAC degrader with DC50s of 0.42 and 0.32 nM in EBC-1 and Hs746T cells, respectively. PROTAC c-Met degrader-5 significantly induces cell apoptosis, G1 cell cycle arrest, and inhibits cell migration and invasion. PROTAC c-Met degrader-5 has potent antiproliferative and degradation efficacy against c-Met-addicted cancer cells and Tepotinib (HY-14721)-resistant cancer cells[1]. Pink: c-Met ligand (HY-W425461); Blue: CRBN ligase ligand (HY-14658); Black: linker

IC50 & Target[1]

p-STAT3

 

In Vivo

PROTAC c-Met degrader-5 (5-10 mg/kg, p.o., qd for 18 days) potently inhibits tumor growth in EBC-1 xenograft mice model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

846.93

Formula

C47H46N10O6
SMILES

O=C1C=CC(C2=CC(C#N)=CC=C2)=NN1CC3=CC(C4=NC=C(C=N4)OCC5CCN(CC5)CCN6CCN(CC6)C7=CC=C(C8=C7)C(N(C8=O)C9C(NC(CC9)=O)=O)=O)=CC=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC c-Met degrader-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC c-Met degrader-5PROTACsc-Met/HGFRApoptosisSTATPROTACDegradationc-MetAntiproliferativeTepotinib-resistantCancerEBC-1 xenograft mice modelEBC-1 cellsHs746T cellsInhibitorinhibitorinhibit

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