2. Anti-infection MAPK/ERK Pathway NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Apoptosis
  3. Bacterial p38 MAPK Reactive Oxygen Species (ROS) Apoptosis Caspase
  4. Periplanetasin-4

Periplanetasin-4 is an antimicrobial peptide that can be derived from the American cockroach (Periplaneta americana). Periplanetasin-4 reduces cell rounding and apoptosis. Periplanetasin-4 blocks Clostridium difficile toxin A-induced ROS production and the activation of downstream p38 MAPK and p21. Periplanetasin-4 significantly increases mitochondrial calcium level, reduces DPH fluorescence intensity and vacuolar dysfunction in Candida albicans ATCC 90028 cells. Periplanetasin-4 significantly ameliorates toxin A-induced mucosal damage in the mouse gut. Periplanetasin-4 can be used for the study of colitis.

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Periplanetasin-4

Periplanetasin-4 Chemical Structure

CAS No. : 2206807-06-7

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Periplanetasin-4 Related Antibodies

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Description

Periplanetasin-4 is an antimicrobial peptide that can be derived from the American cockroach (Periplaneta americana). Periplanetasin-4 reduces cell rounding and apoptosis. Periplanetasin-4 blocks Clostridium difficile toxin A-induced ROS production and the activation of downstream p38 MAPK and p21. Periplanetasin-4 significantly increases mitochondrial calcium level, reduces DPH fluorescence intensity and vacuolar dysfunction in Candida albicans ATCC 90028 cells. Periplanetasin-4 significantly ameliorates toxin A-induced mucosal damage in the mouse gut. Periplanetasin-4 can be used for the study of colitis[1][2].

In Vitro

Periplanetasin-4 (100 μg/mL, 48 h) significantly rescues the loss of cell viability and reduces cell rounding induced by Clostridium difficile toxin A in HT29 cells[1].
Periplanetasin-4 (100 μg/mL, 48 h) markedly decreases the number of TUNEL-positive apoptotic HT29 cells and inhibits the activation of caspase-3 (a hallmark of apoptosis) induced by Clostridium difficile toxin A[1].
Periplanetasin-4 (100 μg/mL, 45 min) completely inhibits the increase in ROS production induced by Clostridium difficile toxin A in HT29 cells[1].
Periplanetasin-4 (100 μg/mL, 4 h) significantly blocks the activation of p38MAPK and the up-regulation of p21 in HT29 cells[1].
Periplanetasin-4 (5 μM, 2-4 h) significantly increases PI influx and DiBAC4(3) accumulation in Candida albicans ATCC 90028 cells[2].
Periplanetasin-4 (5 μM, 2 h) significantly elevates intracellular ROS level, increases mitochondrial superoxide radical and hydrogen peroxide production in Candida albicans ATCC 90028 cells[2].
Periplanetasin-4 (5 μM, 2 h) significantly induces phosphatidylserine externalization and caspase activation in Candida albicans ATCC 90028 protoplasts[2].
Periplanetasin-4 (5 μM, 2 h) significantly increases malondialdehyde (MDA) level, enhances catalase activity and total glutathione content, causes mitochondrial membrane potential collapse, increases mitochondrial biomass, and promotes mitochondrial fragmentation in Candida albicans ATCC 90028 cells[2].
Periplanetasin-4 (5 μM, 2 h) significantly increases BCECF and C-DCFDA fluorescence intensity and mitochondrial calcium level, reduces DPH fluorescence intensity and vacuolar dysfunction in Candida albicans ATCC 90028 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Periplanetasin-4 Related Antibodies

Apoptosis Analysis[1]

Cell Line: Clostridium difficile toxin A induced HT29 cells
Concentration: 100 μg/mL
Incubation Time: 48 h
Result: Decreased the number of TUNEL-positive apoptotic HT29 cells.
Inhibited the activation of caspase-3.
In Vivo

Periplanetasin-4 (100 μg/mL, intraluminal injection into mouse ileal loops, 4 h) significantly ameliorates toxin A-induced mucosal damage in the mouse gut[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Clostridium difficile toxin A-induced mouse enteritis model: 6-week-old mice were anesthetized by intraperitoneal injection of sodium pentobarbital (50 mg/kg)[1]
Dosage: 100 μg/mL co-administered with 3 nM Clostridium difficile toxin A
Administration: Intraluminal injection into mouse ileal loops for 4 h
Result: Ameliorated toxin A-induced mucosal damage in the mouse gut.
Reduced the elevation of interleukin-6 (IL-6) production in the ileal loop tissues of mice.
Molecular Weight

1503.81

Formula

C70H110N20O15S
CAS No.
Sequence

Leu-Arg-His-Lys-Val-Tyr-Gly-Tyr-Cys-Val-Leu-Gly-Pro-NH2
Sequence Shortening

LRHKVYGYCVLGP-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Periplanetasin-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Periplanetasin-42206807-06-7Periplanetasin4Periplanetasin 4Bacterialp38 MAPKReactive Oxygen Species (ROS)ApoptosisCaspasecolitisPeriplaneta Americanap38MAPKp21Clostridium difficile toxin AHT29 cellsInhibitorinhibitorinhibit

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