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  3. HIV
  4. TAT

TAT (YGRKKRRQRRR) is derived from the transactivator of transcription (TAT) of human immunodeficiency virus-1 (HIV-1) and is a cell-penetrating peptide. TAT can increase the yields and the solubility of heterologous proteins.

For research use only. We do not sell to patients.

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TAT Chemical Structure

TAT Chemical Structure

CAS No. : 191936-91-1

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Based on 1 publication(s) in Google Scholar

Other Forms of TAT:

TAT Related Antibodies

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Description

TAT (YGRKKRRQRRR) is derived from the transactivator of transcription (TAT) of human immunodeficiency virus-1 (HIV-1) and is a cell-penetrating peptide. TAT can increase the yields and the solubility of heterologous proteins[1].

IC50 & Target

HIV-1

 

Cellular Effect
Cell Line Type Value Description References
A549 IC50
> 100 μM
Compound: p-02
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by CCK-8 assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by CCK-8 assay
[PMID: 35452935]
BEAS-2B IC50
> 100 μM
Compound: p-02
Cytotoxicity against human BEAS-2B cells assessed as reduction in cell viability measured after 24 hrs by CCK-8 assay
Cytotoxicity against human BEAS-2B cells assessed as reduction in cell viability measured after 24 hrs by CCK-8 assay
[PMID: 35452935]
HepG2 IC50
> 100 μM
Compound: p-02
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 24 hrs by CCK-8 assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 24 hrs by CCK-8 assay
[PMID: 35452935]
L02 IC50
> 100 μM
Compound: p-02
Cytotoxicity against human L02 cells assessed as reduction in cell viability measured after 24 hrs by CCK-8 assay
Cytotoxicity against human L02 cells assessed as reduction in cell viability measured after 24 hrs by CCK-8 assay
[PMID: 35452935]
In Vitro

TAT (YGRKKRRQRRR) represents amino acids 47-57 of the human immunodeficiency virus type I (HIV-1) TAT protein. The positively charged protein transduction domain of the HIV-1 TAT protein (TAT-PTD; residues 47-57 of TAT) rapidly translocates across the plasma membrane of living cells. TAT (YGRKKRRQRRR; TAT-PTD) can cross the hydrophobic lipid bilayer of a cell membrane simply by passive diffusion[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TAT Related Antibodies
Molecular Weight

1559.83

Formula

C64H118N32O14
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg
Sequence Shortening

YGRKKRRQRRR
Structure Classification
Initial Source

HIV-1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (32.05 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6411 mL 3.2055 mL 6.4110 mL
5 mM 0.1282 mL 0.6411 mL 1.2822 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.6411 mL 3.2055 mL 6.4110 mL 16.0274 mL
5 mM 0.1282 mL 0.6411 mL 1.2822 mL 3.2055 mL
10 mM 0.0641 mL 0.3205 mL 0.6411 mL 1.6027 mL
15 mM 0.0427 mL 0.2137 mL 0.4274 mL 1.0685 mL
20 mM 0.0321 mL 0.1603 mL 0.3205 mL 0.8014 mL
25 mM 0.0256 mL 0.1282 mL 0.2564 mL 0.6411 mL
30 mM 0.0214 mL 0.1068 mL 0.2137 mL 0.5342 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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TAT Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAT191936-91-1HIVHuman immunodeficiency virusHIV-1PeptideInhibitorinhibitorinhibit

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