2. GPCR/G Protein PI3K/Akt/mTOR Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Autophagy Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. GCGR PI3K Akt Reactive Oxygen Species (ROS) Autophagy Interleukin Related Sirtuin AMPK Apoptosis
  4. Pegloxenatide

Pegloxenatide  (Synonyms: Polyethylene glycol loxenatide; PEX 168)

Cat. No.: HY-P3491 Purity: 90.00%
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Handling Instructions Technical Support

Pegloxenatide (Polyethylene glycol loxenatide) is a long-acting glucagon-like peptide-1 receptor (GLP-1RA) agonist. Pegloxenatide has various activities such as lowering blood glucose, lowering blood lipids, improving body weight, anti-inflammation, promoting wound healing, protecting the liver, and protecting the heart. Pegloxenatide can be used in the research of type 2 diabetes and its multiple complications.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Pegloxenatide

Pegloxenatide Chemical Structure

CAS No. : 2420483-82-3

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Based on 1 publication(s) in Google Scholar

Pegloxenatide Related Antibodies

Top Publications Citing Use of Products

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Akt Akt1 Akt2 Akt3

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

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Description

Pegloxenatide (Polyethylene glycol loxenatide) is a long-acting glucagon-like peptide-1 receptor (GLP-1RA) agonist. Pegloxenatide has various activities such as lowering blood glucose, lowering blood lipids, improving body weight, anti-inflammation, promoting wound healing, protecting the liver, and protecting the heart. Pegloxenatide can be used in the research of type 2 diabetes and its multiple complications[1][2][3][4].

In Vitro

Pegloxenatide (100-200 nM; 24 h) can activate the PI3K/AKT pathway in high glucose-treated HepG2 cells, while the PI3K inhibitor LY294002 (HY-10108) can inhibit its activation[1].
Pegloxenatide (250 nM; 24 h) can restore tube formation and migratory capacity, increase NO production, reduce mitochondrial ROS generation, improve mitochondrial membrane potential and respiratory function, and restore autophagic flux in human endothelial progenitor cells treated with high glucose and Palmitic acid (HY-N0830)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pegloxenatide Related Antibodies

Western Blot Analysis[1]

Cell Line: High glucose-treated HepG2 cells
Concentration: 100 and 200 nM
Incubation Time: 24 h
Result: Significantly increased the levels of p-PI3K and p-AKT.
In Vivo

Pegloxenatide (0.3-1 mg/kg; subcutaneous injection; once every 3 days; 4 weeks) exerts hypoglycemic and hepatoprotective effects in db/db mice[1].
Pegloxenatide (0.03 mg/kg/week; intraperitoneal injection; 12 weeks) has activities of improving glucose metabolism, anti-inflammation and accelerating wound healing in db/db mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6-db/db male mice[1]
Dosage: 0.3 and 1 mg/kg
Administration: Subcutaneous injection; once every 3 days; 4 weeks
Result: Significantly reduced body weight and fasting glucose, mincreased glucose tolerance, improved serum and liver biochemical parameters, and attenuated hepatic steatosis and liver and pancreatic tissue damages in db/db mice.
Considerably inhibited oxidative stress, decreased pro-inflammatory factor (TNF-α, IL-6, and MCP-1) levels, increased anti-inflammatory factor IL-10 levels, upregulated Sirt1, p-AMPK, and p-ACC expressions in the Sirt1/AMPK/ACC pathway, promoted GLP-1R expression by inhibiting β-cell apoptosis, and activated the insulin PI3K/AKT pathway to exert hypoglycemic and hepatoprotective effects.
Clinical Trial
Formula

(C₂H₄O)n(C₂H₄O)nC₂₀₆H₃₁₇N₅₅O₆₇S
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

Sequence

PEGn-His-{d-Ala}-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-{Nle}-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Gln-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Cys-NH2
Sequence Shortening

PEGn-H-{d-Ala}-EGTFTSDLSKQ-{Nle}-EEEAVRLFIEWLKQGGPSSGAPPPC-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 90.00%

SDS (252 KB)

COA (231 KB)

Handling Instructions (2659 KB)
References
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Pegloxenatide Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pegloxenatide2420483-82-3Polyethylene glycol loxenatide PEX 168PEX168PEX 168PEX-168GCGRPI3KAktReactive Oxygen Species (ROS)AutophagyInterleukin RelatedSirtuinAMPKApoptosisGlucagon ReceptorPhosphoinositide 3-kinasePKBProtein kinase BILAMP-activated protein kinasepolyethylene glycol loxenatidelong-actingglucagon-like peptide-1 receptortype 2 diabetes mellitus (T2DM)db/db male miceInhibitorinhibitorinhibit

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