Sirtuin Inhibitors

Sirtuin

SIRT1

SIRT2

SIRT3

SIRT6

SIRT5

SIRT7

Sirtuin Inhibitors, Agonists, Activators & Modulators

Product Name	Sirtuin	SIRT1	SIRT2	SIRT3	SIRT6	SIRT5	SIRT7	Purity
Nicotinamide		SIRT1, IC₅₀: 50-180 μM	SIRT2, EC₅₀: 2 μM					99.99%
Nicotinamide riboside chloride		SIRT1		SIRT3				99.90%
SKLB-11A				SIRT3, Kd: 4.7 μM				99.40%
3-TYP				SIRT3, IC₅₀: 38 μM				99.96%
Suramin sodium salt		SIRT1, IC₅₀: 297 nM	SIRT2, IC₅₀: 1.15 μM			SIRT5, IC₅₀: 22 μM		98.89%
SRT 1720		SIRT1, EC1.5: 0.16 μM	SIRT2, EC1.5: 37 μM					99.90%
AGK2		SIRT1, IC₅₀: 30 μM	SIRT2, IC₅₀: 3.5 μM	SIRT3, IC₅₀: 91 μM				99.62%
OSS_128167		SIRT1, IC₅₀: 1578 μM	SIRT2, IC₅₀: 751 μM		SIRT6, IC₅₀: 89 μM			98.63%
SRT 2104		SIRT1						99.27%
SIRT7 inhibitor 97491							SIRT7, IC₅₀: 325 nM	98.81%
Sirtinol		ySir2, IC₅₀: 48 μM hSIRT1, IC₅₀: 131 μM	hSIRT2, IC₅₀: 57.7 μM					98.0%
Resveratrol (Standard)	Sirtuin
SRT 1720 monohydrochloride		SIRT1, EC1.5: 0.16 μM SIRT1, EC₅₀: 0.10 μM	SIRT2, EC1.5: 37 μM					99.92%
UBCS039					SIRT6, EC₅₀: 38 μM			98.88%
Thiomyristoyl		SIRT1, IC₅₀: 98 μM	SIRT2, IC₅₀: 28 nM					99.74%
2-APQC				SIRT3, Kd: 2.756				99.70%
SRT 1460		SIRT1, EC1.5: 2.9 μM						98.16%
SirReal2			SIRT2, IC₅₀: 140 nM					99.0%
SRT 1720 dihydrochloride		SIRT1, EC₅₀: 0.10 μM						99.19%
Sweroside		SIRT1						99.76%
Cambinol		SIRT1, IC₅₀: 56 μM	SIRT2, IC₅₀: 59 μM					99.89%
AK-7			SIRT2, IC₅₀: 15.5 μM					99.63%
Agrimol B		SIRT1						99.75%
Tenovin-6		SIRT1, IC₅₀: 21 μM	SIRT2, IC₅₀: 10 μM	SIRT3, IC₅₀: 67 μM				98.00%
Ganoderic acid D				SIRT3				99.40%
SIRT6 activator 12q					SIRT6, EC1.5: 0.58 μM			99.83%
Perindopril				SIRT3				99.56%
Inauhzin		SIRT1						99.49%
Perindopril erbumine				SIRT3				99.98%
Scopolin		SIRT1						99.93%
SIRT1-IN-1		SIRT1, IC₅₀: 0.205 μM	SIRT2, IC₅₀: 11.5 μM	SIRT3, IC₅₀: >100 μM				98.15%
SRT 2183		SIRT1, EC1.5: 0.36 μM						98.06%
Tenovin-1	Sirtuin							99.88%
Nicotinamide (Standard)			SIRT2
CAY10602		SIRT1						98.69%
Phellopterin				SIRT3				99.94%
SIRT-IN-2		SIRT1, IC₅₀: 4 nM	SIRT2, IC₅₀: 1 nM	SIRT3, IC₅₀: 7 nM				98.08%
Dihydrocoumarin		hSIRT1, IC₅₀: 208 μM	hSIRT2, IC₅₀: 295 μM					99.81%
Salermide		SIRT1	SIRT2					98.0%
SIRT5 inhibitor 3						SIRT5, IC₅₀: 5.9 μM		≥98.0%
PROTAC Sirt2 Degrader-1			SIRT2, IC₅₀: 0.25 μM					98.71%
Et-29						SIRT5, Ki: 40 nM		99.89%
Palmitoyl tetrapeptide-20		SIRT1						99.67%
Segetalin B		SIRT1						99.51%
8-Prenylnaringenin		SIRT1						99.63%
5-Heptadecylresorcinol				SIRT3				99.83%
Tenovin-6 Hydrochloride		SIRT1, IC₅₀: 21 μM	SIRT2, IC₅₀: 10 μM	SIRT3, IC₅₀: 67 μM				98.88%
MDL-811					SIRT6, EC₅₀: 5.7 μM			99.68%
AK-1			SIRT2, IC₅₀: 12.5 μM					99.84%
Gardenia yellow				SIRT3
SIRT-IN-1		SIRT1, IC₅₀: 15 nM	SIRT2, IC₅₀: 10 nM	SIRT3, IC₅₀: 33 nM				98.14%
Sirtuin-1 inhibitor 1		SIRT1						98.09%
SIRT2-IN-8			SIRT2					99.32%
SIRT3 activator 2				SIRT3				98.94%
E1231		SIRT1, EC₅₀: 0.83 μM						98.46%
Lumbokinase		SIRT1
SIRT1-IN-3		SIRT1, IC₅₀: 4.2 μM	SIRT2, IC₅₀: 38 μM					99.12%
Sirt2-IN-1			SIRT2, IC₅₀: 163 nM					98.71%
SIRT1-IN-2		SIRT1, IC₅₀: 1.6 μM	SIRT2, IC₅₀: 39 μM					98.31%
Myricanol		SIRT1						≥98.0%
(S)-Selisistat		SIRT1, IC₅₀: 98 nM						99.39%
SIRT1-IN-4		SIRT1, IC₅₀: 10.04 μM						98.62%
RK-9123016			SIRT2, IC₅₀: 0.18 μM					99.65%
YK-3-237		SIRT1						99.54%
Tanshindiol C		SIRT1						98.47%
Ophiopogonin D'		SIRT1						99.90%
SIRT2-IN-9		SIRT1, IC₅₀: ＞300 μM	SIRT2, IC₅₀: 1.3 μM	SIRT3, IC₅₀: ＞300 μM				99.45%
Suramin		SIRT1, IC₅₀: 297 nM	SIRT2, IC₅₀: 1.15 μM			SIRT5, IC₅₀: 22 μM
SIRT2-IN-11		SIRT1, IC₅₀: 118.4 μM	SIRT2, IC₅₀: 18.5 μM					99.94%
Sirtuin modulator 1		SIRT1, EC1.5: 1 μM						99.85%
SIRT3-IN-1				SIRT3, IC₅₀: 0.043 μM				98.47%
YZL-51N							SIRT7, IC₅₀: 12.71 μM
JGB1741		SIRT1, IC₅₀: ∼15 μM	SIRT2, IC₅₀: >100 μM	SIRT3, IC₅₀: >100 μM				99.05%
Palmitoyl tetrapeptide-20 TFA		SIRT1
SIRT6-IN-3		SIRT1, IC₅₀: 80.52 μM	SIRT2, IC₅₀: 92.21 μM		SIRT6, IC₅₀: 7.46 μM			98.19%
AC-93253		SIRT1, IC₅₀: 45.3 μM	SIRT2, IC₅₀: 6 μM	SIRT3, IC₅₀: 24.6 μM				99.3%
MIND4-19			SIRT2, IC₅₀: 7.0 μM					99.93%
SIRT1 activator 2		SIRT1, ED₅₀: <5 μM						99.28%
Nicotinamide riboside malate		SIRT1		SIRT3				98.04%
CrBKA					SIRT6			98.46%
Nicotinamide riboside		SIRT1		SIRT3
CHIC35		SIRT1, IC₅₀: 0.124 μM	SIRT2, IC₅₀: 2.8 μM	SIRT3, IC₅₀: >100 μM
SIRT1/2/3-IN-2		SIRT1	SIRT2	SIRT3
Sirt2-IN-5			SIRT2
SPC-180002		SIRT1, IC₅₀: 1.13 ± 0.3 μM		SIRT3, IC₅₀: 5.41 ± 4.8 μM
Forvisirvat					SIRT6
Epigenetic factor-IN-1							SIRT7
3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol		SIRT1
SirReal-1			SIRT2, IC₅₀: 3.7 μM
Sirt2-IN-6			SIRT2, IC₅₀: 0.815 μM
Nicotinamide Hydrochloride		SIRT1, IC₅₀: 50-180 μM	SIRT2, EC₅₀: 2 μM
hsa62		SIRT1, IC₅₀: 1.3 μM	SIRT2, IC₅₀: 5.5 μM	SIRT3, IC₅₀: 43.6 μM
DCHC		SIRT1
C1A				SIRT3, IC₅₀: 55 μM
SIRT5 inhibitor 5						SIRT5, IC₅₀: 0.21 μM
SIRT5 inhibitor 4		SIRT1, IC₅₀: ＞400 μM	SIRT2, IC₅₀: ＞400 μM	SIRT3, IC₅₀: ＞400 μM	SIRT6, IC₅₀: ＞400 μM	SIRT5, IC₅₀: 26.4 μM	SIRT7, IC₅₀: ＞400 μM
Nicotinamide riboside tartrate		SIRT1		SIRT3
SIRT6 activator 2					SIRT6
Sirt1/2-IN-1		SIRT1, IC₅₀: 1.81 μg/mL	SIRT2, IC₅₀: 2.10 μg/mL	SIRT3, IC₅₀: 20.5 μg/mL
Sirtuin modulator 4		SIRT1, EC₅₀: 51-100 μM
SIRT1-IN-5		SIRT1
SIRT2-IN-14		SIRT1, IC₅₀: >200 μM	SIRT2, IC₅₀: 0.196 μM	SIRT3, IC₅₀: 85.8 μM
SIRT5 inhibitor 2						SIRT5, IC₅₀: 2.3 μM
Sirtuin modulator 5		SIRT1, DC₅₀: ＜50 μM
SL010110			SIRT2
Sirtuin-IN-2						SIRT5
SR94			SIRT2
HSP70/SIRT2-IN-1			SIRT2, IC₅₀: 17.3±2.0 μM
FLS-359			SIRT2, IC₅₀: 3 μM
SIRT6-IN-4		SIRT1, IC₅₀: 311.9 μM	SIRT2, IC₅₀: 157.2 μM	SIRT3, IC₅₀: 274.1 μM	SIRT6, IC₅₀: 5.86 μM
Cudraflavone B		SIRT1
ZINC08792229		SIRT1
SIRT3-IN-2				SIRT3
A2B57			SIRT2, IC₅₀: 6.3 μM
SIRT-IN-6		SIRT1, IC₅₀: >50 μM	SIRT2, IC₅₀: >50 μM	SIRT3, IC₅₀: >50 μM
A1B11			SIRT2, IC₅₀: 5.3 μM
Sweroside (Standard)		SIRT1

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