2. Cell Cycle/DNA Damage Epigenetics Metabolic Enzyme/Protease
  3. Sirtuin Endogenous Metabolite
  4. Nicotinamide riboside malate

Nicotinamide riboside malate, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside malate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside malate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.

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Nicotinamide riboside malate Chemical Structure

Nicotinamide riboside malate Chemical Structure

CAS No. : 2415659-01-5

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Based on 17 publication(s) in Google Scholar

Other Forms of Nicotinamide riboside malate:

Nicotinamide riboside malate Related Antibodies

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Description

Nicotinamide riboside malate, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside malate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities[1]. Nicotinamide riboside malate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease[2].

IC50 & Target[1]

SIRT1

 

SIRT3

 

Human Endogenous Metabolite

 

In Vitro

Nicotinamide riboside malate (0.5 mM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2[1].
Nicotinamide riboside malate increases intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells in a concentration-dependent manner at concentrations ranging from 1-1000 μM[1].
Nicotinamide riboside malate boosts NAD to restore antiviral poly(ADP-ribose) polymerase (PARP) functions to support innate immunity for coronavirus (CoVs), a cause of COVID-19[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nicotinamide riboside malate Related Antibodies

Western Blot Analysis[1]

Cell Line: HEK293T cells
Concentration: 0.5 mM
Incubation Time: 24 hours
Result: Reduced the acetylation status of Ndufa9 and SOD2.
In Vivo

Chronic Nicotinamide riboside malate (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD+ content in a tissue-specific manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 10-week-old C57Bl/6J mice[1]
Dosage: 400 mg/kg
Administration: PO; daily; for 16 weeks
Result: Increased plasma and intracellular NAD+ content in a tissue-specific manner.
Molecular Weight

388.33

Formula

C15H20N2O10
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC(C1=C[N+]([C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)=CC=C1)=O.O[C@H](C(O)=O)CC([O-])=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 116.67 mg/mL (300.44 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5751 mL 12.8756 mL 25.7513 mL
5 mM 0.5150 mL 2.5751 mL 5.1503 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.5751 mL 12.8756 mL 25.7513 mL 64.3782 mL
5 mM 0.5150 mL 2.5751 mL 5.1503 mL 12.8756 mL
10 mM 0.2575 mL 1.2876 mL 2.5751 mL 6.4378 mL
15 mM 0.1717 mL 0.8584 mL 1.7168 mL 4.2919 mL
20 mM 0.1288 mL 0.6438 mL 1.2876 mL 3.2189 mL
25 mM 0.1030 mL 0.5150 mL 1.0301 mL 2.5751 mL
30 mM 0.0858 mL 0.4292 mL 0.8584 mL 2.1459 mL
40 mM 0.0644 mL 0.3219 mL 0.6438 mL 1.6095 mL
50 mM 0.0515 mL 0.2575 mL 0.5150 mL 1.2876 mL
60 mM 0.0429 mL 0.2146 mL 0.4292 mL 1.0730 mL
80 mM 0.0322 mL 0.1609 mL 0.3219 mL 0.8047 mL
100 mM 0.0258 mL 0.1288 mL 0.2575 mL 0.6438 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Nicotinamide riboside malate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nicotinamide riboside2415659-01-5SirtuinEndogenous MetaboliteNAD+oxidativemetabolismmetabolicabnormalitiesdietarysupplementsorallyvitaminB3niacinAlzheimer’sCOVID-19PARPInhibitorinhibitorinhibit

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