2. Cell Cycle/DNA Damage Epigenetics Autophagy
  3. Sirtuin Autophagy
  4. SKLB-11A

SKLB-11A is a potent allosteric SIRT3 (sirtuin 3) agonist. SKLB-11A activates autophagy-related signaling pathways, prevents mitochondrial dysfunction, improves cardiac function in Doxorubicin (HY-15142A)-induced cardiotoxicity and myocardial ischemia/reperfusion models.

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SKLB-11A Chemical Structure

SKLB-11A Chemical Structure

CAS No. : 433953-86-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
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10 mg In-stock
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Based on 1 publication(s) in Google Scholar

SKLB-11A Related Antibodies

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Description

SKLB-11A is a potent allosteric SIRT3 (sirtuin 3) agonist. SKLB-11A activates autophagy-related signaling pathways, prevents mitochondrial dysfunction, improves cardiac function in Doxorubicin (HY-15142A)-induced cardiotoxicity and myocardial ischemia/reperfusion models[1].

IC50 & Target

SIRT3

 

Molecular Weight

350.35

Formula

C19H15FN4O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

COC(C1=C(N)N(CC2=CC=C(F)C=C2)C3=NC4=CC=CC=C4N=C31)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 7.78 mg/mL (22.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8543 mL 14.2714 mL 28.5429 mL
5 mM 0.5709 mL 2.8543 mL 5.7086 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8543 mL 14.2714 mL 28.5429 mL 71.3572 mL
5 mM 0.5709 mL 2.8543 mL 5.7086 mL 14.2714 mL
10 mM 0.2854 mL 1.4271 mL 2.8543 mL 7.1357 mL
15 mM 0.1903 mL 0.9514 mL 1.9029 mL 4.7571 mL
20 mM 0.1427 mL 0.7136 mL 1.4271 mL 3.5679 mL
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SKLB-11A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SKLB-11A433953-86-7SirtuinAutophagySIRT3autophagycardiotoxicityischemia/reperfusionInhibitorinhibitorinhibit

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