Palmitoyl tetrapeptide-20 TFA (Synonyms: PTP20 TFA)

Cat. No.: HY-P5247A: Data Sheet Handling Instructions
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Palmitoyl tetrapeptide-20 (PTP20) TFA is a biomimetic peptide agonist of α-MSH. Palmitoyl tetrapeptide-20 TFA promotes hair pigmentation and delays hair graying by activating the MC1-R pathway (AC₅₀: 0.16 nM), enhancing catalase activity to reduce H₂O₂ accumulation, and upregulating SIRT1 activity. Palmitoyl tetrapeptide-20 TFA can be used in research on preventing hair loss and improving hair graying.

For research use only. We do not sell to patients.

Palmitoyl tetrapeptide-20 TFA Chemical Structure

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This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Palmitoyl tetrapeptide-20 TFA:

Palmitoyl tetrapeptide-20

Other Forms of Palmitoyl tetrapeptide-20 TFA:

Palmitoyl tetrapeptide-20 In-stock

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•Related Small Molecules:

•Related Proteins:

View All Melanocortin Receptor Isoform Specific Products:

View All Isoforms

MC1R MC3R MC2R MC4R MC5R

View All Sirtuin Isoform Specific Products:

View All Isoforms

Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

MC1R

SIRT1

In Vitro

Palmitoyl tetrapeptide-20 (0.1-1 μM; 72 h) TFA promotes melanin production in human melanocytes^[1].
Palmitoyl tetrapeptide-20 (18 h) TFA reduces intracellular H₂O₂ levels in human follicle dermal papilla cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

739.00 (free base)

Formula

C₃₈H₇₀N₆O₈.xC₂HF₃O₂

Sequence

{Pal}-Pro-Glu-Lys-Lys

Sequence Shortening

{Pal}-PEKK

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Almeida Scalvino S, et al. Efficacy of an agonist of α-MSH, the palmitoyl tetrapeptide-20, in hair pigmentation. Int J Cosmet Sci. 2018 Oct;40(5):516-524. [Content Brief]

Palmitoyl tetrapeptide-20 TFA Related Classifications

Metabolic Disease Inflammation/Immunology

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Palmitoyl tetrapeptide-20PTP20Palmitoyl tetrapeptide20Palmitoyl tetrapeptide 20PTP 20PTP-20Melanocortin ReceptorSirtuinMC Receptorα-MSHhair pigmentationhair greyingmelanocytesfollicle dermal papilla cellsInhibitorinhibitorinhibit

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