2. Cell Cycle/DNA Damage Epigenetics
  3. Sirtuin
  4. Forvisirvat

Forvisirvat (SP-624) is an orally active, brain-penetrant and selective sirtuin 6 (SIRT6) activator. Forvisirvat activates the deacetylase activity of SIRT6, enhancing DNA repair and mitochondrial health, and exhibits antidepressant activity in animal models. Forvisirvat is promising for research of major depressive disorder.

For research use only. We do not sell to patients.

Forvisirvat

Forvisirvat Chemical Structure

CAS No. : 2135638-06-9

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Forvisirvat Related Antibodies

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Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7

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Description

Forvisirvat (SP-624) is an orally active, brain-penetrant and selective sirtuin 6 (SIRT6) activator. Forvisirvat activates the deacetylase activity of SIRT6, enhancing DNA repair and mitochondrial health, and exhibits antidepressant activity in animal models. Forvisirvat is promising for research of major depressive disorder[1].

IC50 & Target

SIRT6

 

Molecular Weight

404.80

Formula

C19H17ClN2O6
CAS No.
SMILES

O=C1[C@]2(C(OC)=CC(C[C@H]2C)=O)OC3=C(Cl)C(C4=NN=C(C)O4)=CC(OC)=C31
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Forvisirvat Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Forvisirvat2135638-06-9SP-624SP624SP 624SirtuinSIRT6DNA repairmitochondrial healthantidepressant activityInhibitorinhibitorinhibit

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