2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. Sirtuin Apoptosis
  4. SIRT2-IN-18

SIRT2-IN-18 (Compound 8) is a SIRT2 inhibitor with IC50s of 5.3  and 12.3 μM for SmSIRT2 and hSIRT2, respectively. SIRT2-IN-18 shows potent antischistosomal activities against both Liberian and Puerto Rican strains of Schistosoma mansoni and reduces schistosomula and adult worm pair viability, pairing, and egg production, with low cytotoxicity in mammalian cells. SIRT2-IN-18 increases histone H3 hyperacetylation and induces cytochrome c-mediated apoptosis.

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SIRT2-IN-18

SIRT2-IN-18 Chemical Structure

CAS No. : 858032-59-4

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SIRT2-IN-18 Related Antibodies

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Description

SIRT2-IN-18 (Compound 8) is a SIRT2 inhibitor with IC50s of 5.3  and 12.3 μM for SmSIRT2 and hSIRT2, respectively. SIRT2-IN-18 shows potent antischistosomal activities against both Liberian and Puerto Rican strains of Schistosoma mansoni and reduces schistosomula and adult worm pair viability, pairing, and egg production, with low cytotoxicity in mammalian cells. SIRT2-IN-18 increases histone H3 hyperacetylation and induces cytochrome c-mediated apoptosis[1].

IC50 & Target[1]

hSIRT2

12.3 μM (IC50)

Schistosoma mansoniSIRT2

5.3 μM (IC50)

Molecular Weight

340.33

Formula

C21H12N2O3
CAS No.
SMILES

O=C(C1=CC2=C(OC1=NC3=O)C=CC4=C2C=CC=C4)N3C5=CC=CC=C5
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Purity & Documentation
References
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SIRT2-IN-18 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SIRT2-IN-18858032-59-4SirtuinApoptosisSIRT2AntischistosomalHistone H3Cytochrome cL929 cellsBJ fibroblastsInhibitorinhibitorinhibit

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