2. Cell Cycle/DNA Damage Epigenetics
  3. Sirtuin
  4. SIRT1 activator 2

SIRT1 activator 2 (compound 212) is a SIRT1 activator with an ED50 of < 5 μM. SIRT1 activator 2 can be used for increasing the lifespan of a cell.

For research use only. We do not sell to patients.

SIRT1 activator 2 Chemical Structure

SIRT1 activator 2 Chemical Structure

CAS No. : 863589-52-0

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SIRT1 activator 2 Related Antibodies

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Description

SIRT1 activator 2 (compound 212) is a SIRT1 activator with an ED50 of < 5 μM. SIRT1 activator 2 can be used for increasing the lifespan of a cell[1].

IC50 & Target[1]

SIRT1

<5 μM (ED50)

Molecular Weight

361.42

Formula

C20H15N3O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC(OC)=CC=C1)NC2=CC=CC(C3=NC4=CC=CN=C4S3)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (13.83 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7669 mL 13.8343 mL 27.6686 mL
5 mM 0.5534 mL 2.7669 mL 5.5337 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7669 mL 13.8343 mL 27.6686 mL 69.1716 mL
5 mM 0.5534 mL 2.7669 mL 5.5337 mL 13.8343 mL
10 mM 0.2767 mL 1.3834 mL 2.7669 mL 6.9172 mL
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SIRT1 activator 2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SIRT1 activator 2863589-52-0Sirtuinsirtuin-modulatingagingstressdiabetesobesityneurodegenerative diseasescardiovascular diseaseblood clotting disordersinflammationcancerflushingmitochondrial activitySIRT1 activatorInhibitorinhibitorinhibit

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