2. MAPK/ERK Pathway Cell Cycle/DNA Damage
  3. SOS1 PERK
  4. SOS1-IN-22

SOS1-IN-22 is a son of sevenless homolog 1 (SOS1) inhibitor. SOS1-IN-22 can inhibit KRAS-G12C/SOS1 complex formation with an IC50 value of 40.28 nM. SOS1-IN-22 can reduce phosphorylation ERK levels. SOS1-IN-22 can be used for the research of cancer, such as pancreatic carcinoma and appendiceal carcinoma.

For research use only. We do not sell to patients.

SOS1-IN-22

SOS1-IN-22 Chemical Structure

CAS No. : 3092445-74-1

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SOS1-IN-22 Related Antibodies

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Description

SOS1-IN-22 is a son of sevenless homolog 1 (SOS1) inhibitor. SOS1-IN-22 can inhibit KRAS-G12C/SOS1 complex formation with an IC50 value of 40.28 nM. SOS1-IN-22 can reduce phosphorylation ERK levels. SOS1-IN-22 can be used for the research of cancer, such as pancreatic carcinoma and appendiceal carcinoma[1].

In Vitro

SOS1-IN-22 (Compound A15f) (72 h) shows proliferation-inhibitory activity with an IC50 of 1.03 μM in K562 cells[1].
SOS1-IN-22 (0-10000 nM) inhibits KRAS-G12C/SOS1 complex formation[1].
SOS1-IN-22 (0-300 nM, 2 h) dose-dependently decreases pERK levels in K562 cells[1].
SOS1-IN-22 (1-10 nM, 2 h) significantly enhances suppression of pERK expression combined within AMG510 (HY-114277) (20 nM) in MIAPaCa-2 cells[1].
SOS1-IN-22 (0.0001-10 μM, 72 h) does not exhibit significant cytotoxicity in HL-7702 and 5k cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SOS1-IN-22 Related Antibodies

Western Blot Analysis[1]

Cell Line: MIAPaCa-2 cells
Concentration: 1 and 10 μM
Incubation Time: 2 h, combined within AMG510 (HY-114277) (20 nM)
Result: Decreased pERK levels.
Molecular Weight

462.51

Formula

C24H29F3N4O2
CAS No.
SMILES

O=C1C(C)(C)C2=NC(C)=NC(N[C@H](C)C3=CC=CC(C(F)F)=C3F)=C2CN1C4CCOCC4
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SOS1-IN-22 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SOS1-IN-223092445-74-1SOS1PERKRas/Rac guanine nucleotide exchange factor 1Protein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinaseKRAS-G12CERKK562HL-77025kInhibitorinhibitorinhibit

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