TREM-1 inhibitory peptide M3

Name: TREM-1 inhibitory peptide M3
Brand: MedChemExpress
SKU: HY-P10089
Rating: 4.5 (1 reviews)

Cat. No.: HY-P10089 Purity: 99.10%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

TREM-1 inhibitory peptide M3 is a ligand-dependent TREM-1 antagonist. TREM-1 inhibitory peptide M3 can inhibit systemic and pulmonary pro-inflammatory cytokine and chemokine production and attenuate acute lung injury.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

TREM-1 inhibitory peptide M3 Chemical Structure

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

795.89

Formula

C₃₆H₅₃N₁₃O₈

Appearance

Solid

Color

White to off-white

Sequence

Arg-Gly-Phe-Phe-Arg-Gly-Gly

Sequence Shortening

RGFFRGG

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (125.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 100 mg/mL (125.65 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2565 mL	6.2823 mL	12.5645 mL
5 mM	0.2513 mL	1.2565 mL	2.5129 mL
10 mM	0.1256 mL	0.6282 mL	1.2565 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.14 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (3.14 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.10%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (246 KB) RP-HPLC (243 KB) LCMS (92 KB) Elemental Analysis Report (105 KB)

Handling Instructions (2659 KB)

References

[1]. Denning NL, et, al. Inhibition of a triggering receptor expressed on myeloid cells-1 (TREM-1) with an extracellular cold-inducible RNA-binding protein (eCIRP)-derived peptide protects mice from intestinal ischemia-reperfusion injury. Surgery. 2020 Sep;168(3):478-485. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	1.2565 mL	6.2823 mL	12.5646 mL	31.4114 mL
	5 mM	0.2513 mL	1.2565 mL	2.5129 mL	6.2823 mL
	10 mM	0.1256 mL	0.6282 mL	1.2565 mL	3.1411 mL
	15 mM	0.0838 mL	0.4188 mL	0.8376 mL	2.0941 mL
	20 mM	0.0628 mL	0.3141 mL	0.6282 mL	1.5706 mL
	25 mM	0.0503 mL	0.2513 mL	0.5026 mL	1.2565 mL
	30 mM	0.0419 mL	0.2094 mL	0.4188 mL	1.0470 mL
	40 mM	0.0314 mL	0.1571 mL	0.3141 mL	0.7853 mL
	50 mM	0.0251 mL	0.1256 mL	0.2513 mL	0.6282 mL
	60 mM	0.0209 mL	0.1047 mL	0.2094 mL	0.5235 mL
	80 mM	0.0157 mL	0.0785 mL	0.1571 mL	0.3926 mL
	100 mM	0.0126 mL	0.0628 mL	0.1256 mL	0.3141 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.