2. Epigenetics
  3. RNA MTase
  4. SA91-0178

SA91-0178 is a METTL1 inhibitor. SA91-0178 inhibits m7G methylation of RNA, reduces SARM1 stability, mitigates NAD+ depletion and metabolic reprogramming in macrophages. SA91-0178 demonstrates excellent protective efficacy against multiple organ injury in cecal ligation and puncture (CLP)-induced and ischemia/reperfusion (I/R)-induced mice. SA91-0178 can be used for the study of systemic inflammatory diseases.

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SA91-0178

SA91-0178 Chemical Structure

CAS No. : 2244341-81-7

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SA91-0178 Related Antibodies

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Description

SA91-0178 is a METTL1 inhibitor. SA91-0178 inhibits m7G methylation of RNA, reduces SARM1 stability, mitigates NAD+ depletion and metabolic reprogramming in macrophages. SA91-0178 demonstrates excellent protective efficacy against multiple organ injury in cecal ligation and puncture (CLP)-induced and ischemia/reperfusion (I/R)-induced mice. SA91-0178 can be used for the study of systemic inflammatory diseases[1].

In Vitro

SA91-0178 inhibits LPS (HY-D1056)-induced TNF-α and IL-1β secretion in mouse bone marrow-derived macrophages (BMDMs) without cytotoxicity[1].
SA91-0178 attenuates LPS-induced m7G modification in RAW264.7 cells and human peripheral blood mononuclear cell (PBMC)-derived macrophages[1].
SA91-0178 reduces luciferase activity of wild-type SARM1 3'UTR reporter in shMETTL1-treated THP-1-derived macrophages[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SA91-0178 Related Antibodies
In Vivo

SA91-0178 (5-15 mg/kg, ip, once) demonstrates protective effects against multiple organ injury in cecal ligation and puncture (CLP)-induced septic C57BL/6 mice, while failing in Lyz2creMettl1fl/fl mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-week-old male C57BL/6 mice, Lyz2creMettl1fl/fl mice were ligated and punctured, and a small amount of cecal content was extruded by gentle squeezing [1]
Dosage: 5, 10, 15 mg/kg
Administration: ip, once
Result: Achieved reduction rates of serum Cre, BUN, AST, and ALT.
Reduced the renal tubular injury score.
Appeared decreased F4/80+ macrophage infiltration in kidney, liver, lung, and heart.
Showed greater reduction in SARM1 mRNA/protein levels in F4/80+ macrophages.
Molecular Weight

469.53

Formula

C28H27N3O4
CAS No.
SMILES

O=C(O)C1=CC=CC(CNC(C2=CC=C(N(C)C(C34CCN(C5=CC=CC=C5)CC4)=O)C3=C2)=O)=C1
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Purity & Documentation
References
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SA91-0178 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SA91-01782244341-81-7RNA MTaseRNA MethyltransferaseMETTLinflammatory diseasesMETTL1macrophagesInhibitorinhibitorinhibit

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