2. GPCR/G Protein Neuronal Signaling
  3. Mas-related G-protein-coupled Receptor (MRGPR) Neuropeptide Y Receptor
  4. Neuropeptide AF (cattle)

Neuropeptide AF (cattle), an amidated octadecapeptide, is RFamide neuropeptide. Neuropeptide AF (cattle) acts as a ligand of Mas-related gene receptor A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR)) (EC50 of ~60 nM) and MrgprC11 (EC50 of ~300 nM). Neuropeptide AF (cattle) also activate to the G protein-coupled receptors NPFF1 (Neuropeptide Y Receptor) (EC50 of ~25-325 nM) and NPFF2 (EC50 of ~1-5 nM). Neuropeptide AF (cattle) shows anti-opiate and related pain modulation effects.

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Neuropeptide AF (cattle)

Neuropeptide AF (cattle) Chemical Structure

CAS No. : 99588-52-0

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Neuropeptide AF (cattle) Related Antibodies

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Description

Neuropeptide AF (cattle), an amidated octadecapeptide, is RFamide neuropeptide. Neuropeptide AF (cattle) acts as a ligand of Mas-related gene receptor A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR)) (EC50 of ~60 nM) and MrgprC11 (EC50 of ~300 nM). Neuropeptide AF (cattle) also activate to the G protein-coupled receptors NPFF1 (Neuropeptide Y Receptor) (EC50 of ~25-325 nM) and NPFF2 (EC50 of ~1-5 nM). Neuropeptide AF (cattle) shows anti-opiate and related pain modulation effects[1][2].

In Vitro

Neuropeptide AF (NPAF) (50, 100, 150, 300, and 600 nM) induces a piecemeal degranulation in bone marrow-derived mucosal mast cells (BMMCs). Neuropeptide AF can be considered as a novel modulator of BMMC activity in the neuro-immune communication in the gastrointestinal tract[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Neuropeptide AF (cattle) Related Antibodies
In Vivo

Neuropeptide AF (cattle) (0.25 μg/2 μL; i.c.v.; 30 min prior to the tests) decreases the immobility time and increases the climbing and swimming times in modified mouse forced swimming test (mFST)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CFLP mice (25-28 g)[2]
Dosage: 0.25 μg/2 μL
Administration: i.c.v.; 30 min prior to the tests
Result: Decreased the immobility time and increased the climbing and swimming times.
Molecular Weight

1920.13

Formula

C89H130N24O24
CAS No.
Sequence Shortening

AGEGLSSPFWSLAAPQRF-NH2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Neuropeptide AF (cattle) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neuropeptide AF (cattle)99588-52-0Mas-related G-protein-coupled Receptor (MRGPR)Neuropeptide Y ReceptorNPY receptorMrgprA4MrgprC11NPFF1NPFF2anti-opiatepain modulationoctadecapeptideneuropeptideInhibitorinhibitorinhibit

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