2. PI3K/Akt/mTOR Apoptosis
  3. Akt Apoptosis
  4. AKT-IN-27

AKT-IN-27 (4a) is a potential anticancer agent through selective therapeutic targeting of Akt-driven pathways. AKT-IN-27 (4a) induces apoptosis via caspase-3 activation, G2/M cell cycle arrest, and mitochondrial membrane potential disruption. AKT-IN-27 (4a) can be used in the research for TNBC (triple-negative breast cancer).

For research use only. We do not sell to patients.

AKT-IN-27 Chemical Structure

AKT-IN-27 Chemical Structure

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AKT-IN-27 Related Antibodies

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Description

AKT-IN-27 (4a) is a potential anticancer agent through selective therapeutic targeting of Akt-driven pathways. AKT-IN-27 (4a) induces apoptosis via caspase-3 activation, G2/M cell cycle arrest, and mitochondrial membrane potential disruption. AKT-IN-27 (4a) can be used in the research for TNBC (triple-negative breast cancer)[1].

In Vitro

AKT-IN-27 (4a) exhibits IC50 values of 3.29 μM, 4.81 μM, 3.99 μM and 7.25 μM in MDA-MB-231, A549, HeLa and HepG2 cells, respectively. AKT-IN-27 (4a) induces mitochondrial dysfunction in MDA-MB-231 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AKT-IN-27 Related Antibodies
Molecular Weight

377.41

Formula

C21H15NO4S
SMILES

O=C(C1=C(NC2=CC=CC=C2)SC(C3=O)=C1C(C4=C3C=CC=C4)=O)OCC
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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AKT-IN-27 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AKT-IN-27AktApoptosisPKBProtein kinase BMDA-MB-231A549HeLaHepG2TNBCInhibitorinhibitorinhibit

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