2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. CB096

CB096 binds the 5′CGG/3′GGC internal loop structure of r(G4C2)exp RNA, interrupts its gain-of-function mechanism, and thus results in the regulation of nucleolar focusing, RNA splicing defects, RNA metabolism, nucleocytoplasmic transport dysfunction, and toxic dipeptide repeats (DPRs) generated by RNA translation. CB096 inhibits the RAN translation with an IC50 of 20 μM in HEK293T cells.

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CB096 Chemical Structure

CB096 Chemical Structure

CAS No. : 108883-90-5

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Based on 1 publication(s) in Google Scholar

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Description

CB096 binds the 5′CGG/3′GGC internal loop structure of r(G4C2)exp RNA, interrupts its gain-of-function mechanism, and thus results in the regulation of nucleolar focusing, RNA splicing defects, RNA metabolism, nucleocytoplasmic transport dysfunction, and toxic dipeptide repeats (DPRs) generated by RNA translation. CB096 inhibits the RAN translation with an IC50 of 20 μM in HEK293T cells[1].

Molecular Weight

285.25

Formula

C14H11N3O4
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

OC1=CC=C(C2=NC3=CC=C([N+]([O-])=O)C=C3N2)C=C1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (175.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5057 mL 17.5285 mL 35.0570 mL
5 mM 0.7011 mL 3.5057 mL 7.0114 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5057 mL 17.5285 mL 35.0570 mL 87.6424 mL
5 mM 0.7011 mL 3.5057 mL 7.0114 mL 17.5285 mL
10 mM 0.3506 mL 1.7528 mL 3.5057 mL 8.7642 mL
15 mM 0.2337 mL 1.1686 mL 2.3371 mL 5.8428 mL
20 mM 0.1753 mL 0.8764 mL 1.7528 mL 4.3821 mL
25 mM 0.1402 mL 0.7011 mL 1.4023 mL 3.5057 mL
30 mM 0.1169 mL 0.5843 mL 1.1686 mL 2.9214 mL
40 mM 0.0876 mL 0.4382 mL 0.8764 mL 2.1911 mL
50 mM 0.0701 mL 0.3506 mL 0.7011 mL 1.7528 mL
60 mM 0.0584 mL 0.2921 mL 0.5843 mL 1.4607 mL
80 mM 0.0438 mL 0.2191 mL 0.4382 mL 1.0955 mL
100 mM 0.0351 mL 0.1753 mL 0.3506 mL 0.8764 mL
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CB096 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CB096108883-90-5CB 096CB-096DNA/RNA SynthesisHEK293Tamyotrophic lateral sclerosisfrontotemporal dementiaALSFTDInhibitorinhibitorinhibit

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