Anti-Rat FcRn heavy chain heterodimers Antibody (1G3)

Cat. No.: HY-P990818 Purity: ≥95.0%: Data Sheet
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Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) is an anti-rat FcRn heavy chain heterodimers IgG1 monoclonal antibody. Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) can effectively bind to FcRn and competitively inhibit the binding of IgG to FcRn. Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) can reduce the total serum IgG level. Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) can be used for researches on autoimmune conditions such as experimental autoimmune myasthenia gravis (EAMG). The recommend isotype control of Anti-Rat FcRn heavy chain heterodimers Antibody (1G3): Mouse IgG1 kappa, Isotype Control (HY-P99977).

For research use only. We do not sell to patients.

Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Description

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Rat

IC₅₀ & Target

FcRn heavy chain heterodimers

In Vivo

Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) (1-30 mg/kg, i.p., at 2 and 24 h before disease induction with AChR mAb 35) almost completely prevents disease symptoms in female Lewis rats with an experimental autoimmune myasthenia gravis (EAMG) model^[1].
Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) (30 mg/kg, i.p., 3 times a week) significantly alleviate disease symptoms in female Lewis rats with an experimental autoimmune myasthenia gravis (EAMG) model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	AChR mAb 35 (0.75-1 mg/kg) induced female Lewis rats (100 g)^[1]
Dosage:	1, 3, 10 and 30 mg/kg
Administration:	Intraperitoneal injection (i.p.), at 2 and 24 h before disease induction with AChR mAb 35
Result:	Significantly reduced disease score at 30 mg/kg. Significantly reduced serum mAb 35 level. Maintained normal weight and grip strength, while the control group decreased.

Animal Model:	AChR and CFA (HY-153808) induced female Lewis rats (6-7 weeks, 150 g)^[1]
Dosage:	30 mg/kg
Administration:	Intraperitoneal injection (i.p.), 3 times a week
Result:	Significantly reduced disease score. Reduced serum total IgG and anti-AChR IgG levels, but did not affect IgM. Had no effect on spleen and lymph node weight.

Application

ELISA, FACS, Functional assay, Research in vivo

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Rat FcRn heavy chain heterodimers Antibody (1G3)]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (260 KB) SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (602 KB)

References

[1]. Liu L, et al. Amelioration of experimental autoimmune myasthenia gravis in rats by neonatal FcR blockade. J Immunol. 2007 Apr 15;178(8):5390-8. [Content Brief]

[2]. Kenniston JA, et al. Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody. J Biol Chem. 2017 Oct 20;292(42):17449-17460. [Content Brief]

Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) Related Classifications

Inflammation/Immunology

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Rat FcRn heavy chain heterodimers Antibody (1G3)Fc Receptor (FcR)Fc ReceptorFcRnIgGEAMGInhibitorinhibitorinhibit

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