2. JAK/STAT Signaling Stem Cell/Wnt Protein Tyrosine Kinase/RTK Apoptosis
  3. STAT Src Apoptosis
  4. STAT-3/c-Src-IN-1

STAT-3/c-Src-IN-1 (Compound 12d) is a dual STAT-3 (IC50=0.844 μM) and c-Src (IC50=0.268 μM) inhibitor. STAT-3/c-Src-IN-1 blocks tumor cell proliferation, migration, and angiogenesis signaling pathways. STAT-3/c-Src-IN-1 exhibits potent anti-proliferative activity against melanoma (SK-MEL-2) and CNS cancer (SNB-75) cell lines (GI50=-5.75 μM and -5.63 μM), inducing tumor cell apoptosis via G0/G1 and G2/M phase cell cycle arrest. STAT-3/c-Src-IN-1 is promising for research of melanoma and glioblastoma.

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STAT-3/c-Src-IN-1

STAT-3/c-Src-IN-1 Chemical Structure

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STAT-3/c-Src-IN-1 Related Antibodies

Top Publications Citing Use of Products

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STAT3 STAT5 STAT6 STAT1

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Lck Fyn Blk Hck Lyn Yes SRC-3

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Description

STAT-3/c-Src-IN-1 (Compound 12d) is a dual STAT-3 (IC50=0.844 μM) and c-Src (IC50=0.268 μM) inhibitor. STAT-3/c-Src-IN-1 blocks tumor cell proliferation, migration, and angiogenesis signaling pathways. STAT-3/c-Src-IN-1 exhibits potent anti-proliferative activity against melanoma (SK-MEL-2) and CNS cancer (SNB-75) cell lines (GI50=-5.75 μM and -5.63 μM), inducing tumor cell apoptosis via G0/G1 and G2/M phase cell cycle arrest. STAT-3/c-Src-IN-1 is promising for research of melanoma and glioblastoma[1].

IC50 & Target

STAT3

0.844 μM (IC50)

Molecular Weight

585.59

Formula

C28H23N7O6S
SMILES

O=C(CN1C(C2=CC=CC=C2N=C1C)=O)N/N=C/C3=CN(C4=CC=C(C=C4)S(=O)(C)=O)N=C3C(C=C5)=CC=C5[N+]([O-])=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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STAT-3/c-Src-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STAT-3/c-Src-IN-1STATSrcApoptosisSTAT-3c-Srcanti-proliferativemelanoma and glioblastomaInhibitorinhibitorinhibit

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