2. Protein Tyrosine Kinase/RTK
  3. Insulin Receptor
  4. human GIP(3-30), amide TFA

Human GIP(3-30), amide TFA is the TFA salt form of human GIP(3-30), amide (HY-P10138). Human GIP(3-30), amide TFA is a high affinity antagonist of the human GIP receptor in vitro. Human GIP(3-30), amide TFA has potential anti-obesity and anti-diabetic effects.

For research use only. We do not sell to patients.

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human GIP(3-30), amide TFA Chemical Structure

human GIP(3-30), amide TFA Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of human GIP(3-30), amide TFA:

human GIP(3-30), amide TFA Related Antibodies

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Description

Human GIP(3-30), amide TFA is the TFA salt form of human GIP(3-30), amide (HY-P10138). Human GIP(3-30), amide TFA is a high affinity antagonist of the human GIP receptor in vitro. Human GIP(3-30), amide TFA has potential anti-obesity and anti-diabetic effects[1][2].

In Vitro

Human GIP(3-30), amide TFA (0.01-10 µM, 20 min) competitively binds to GIP receptor (GIPR), blocking GIP-mediated cAMP accumulation (Ki=16.8 nM), β-arrestin recruitment (Ki for β-arrestin-1/2 recruitment is 10.6 nM and 10.2 nM) and receptor internalization[2].
Human GIP(3-30), amide TFA (0.01-10 µM, 30 min) inhibits GIP mediated insulin secretion and signal transduction in adipocytes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

human GIP(3-30), amide TFA Related Antibodies
Molecular Weight

3297.69 (free base)

Formula

C150H226N38O44S.xC2HF3O2
Appearance

Solid

Color

White to off-white

Sequence

Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-NH2
Sequence Shortening

EGTFISDYSIAMDKIHQQDFVNWLLAQK-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Purity & Documentation
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human GIP(3-30), amide TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

human GIP(3-30), amideInsulin ReceptorGIP receptorGlucose-dependent insulinotropicpolypeptide receptorantagonistcAMPcompetition bindingpancreatic hormone secretionInhibitorinhibitorinhibit

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