2. GPCR/G Protein
  3. Free Fatty Acid Receptor
  4. LY3104607

LY3104607 is a potent and selective G protein-coupled receptor 40 (GPR40) agonist. LY3104607 can be used in research of diabetes.

For research use only. We do not sell to patients.

LY3104607

LY3104607 Chemical Structure

CAS No. : 1795232-22-2

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Description

LY3104607 is a potent and selective G protein-coupled receptor 40 (GPR40) agonist. LY3104607 can be used in research of diabetes[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
108 nM
Compound: 4; LY3104607
Agonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay
Agonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay
[PMID: 29236497]
HEK293 EC50
11 nM
Compound: 4; LY3104607
Agonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assay
Agonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assay
[PMID: 29236497]
HEK293 EC50
119 nM
Compound: 6
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by calcium-4 dye based FLIPR assay
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by calcium-4 dye based FLIPR assay
[PMID: 27825762]
Molecular Weight

439.51

Formula

C27H25N3O3
CAS No.
SMILES

CC(C=CC=C1C)=C1C2=NN3C(C=CC(COC4=CC=C([C@@H](C#CC)CC(O)=O)C=C4)=C3)=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LY3104607 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY31046071795232-22-2LY 3104607LY-3104607Free Fatty Acid ReceptorFFARInhibitorinhibitorinhibit

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HY-111116
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