FLT3-IN-34 

FLT3-IN-34 is a FLT3 inhibitor, with an IC₅₀ value of 1.4 nM. FLT3-IN-34 blocks the phosphorylation of FLT3 and its downstream signaling molecules AKT and ERK1/2. FLT3-IN-34 induces concentration-dependent G0/G1 phase arrest and mild apoptosis in FLT3-ITD-positive MV4-11 cells. FLT3-IN-34 shows potent anti-proliferative activity against FLT3-ITD-positive MV4-11 cells (IC₅₀ = 14.95 nM) and MOLM-13 (IC₅₀ = 18.5 nM). FLT3-IN-34 can be used for the study of FLT3-positive acute myeloid leukemia (AML)^[1].

FLT3-IN-34 (Compound ZY12) exhibits excellent inhibitory potency against FLT3-ITD kinase, with an IC₅₀ value of 1.4 nM^[1].
FLT3-IN-34 shows potent antiproliferative activity against FLT3-ITD-positive MV4-11 cells (IC₅₀ = 14.95 nM) and MOLM-13 (IC₅₀ = 18.5 nM)^[1].
FLT3-IN-34 (5-20 nM, 24 h) concentration-dependently induces G0/G1 phase arrest of MV4-11 cells and induces MV4-11 cell apoptosis^[1].
FLT3-IN-34 (5-20 nM) significantly blocks the phosphorylation of FLT3, AKT, and ERK1/2 in MV4-11 and MOLM-13 cells, inhibiting the FLT3 signaling pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FLT3-IN-34 (Compound ZY12) (30 mg/kg, p.o., once daily, 10 days) fails to obviously inhibit tumor growth in 4-6 weeks old BALB/c-nu mice bearing MV4-11 subcutaneous xenografts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

417.46

C₂₃H₂₃N₅O₃

3020729-11-4

O=C(NC1=CC=C(C(C2=CN=C3C=C(C)C=CN32)=O)C=C1)NC4=NOC(C(C)(C)C)=C4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Huang Q, et al. Machine learning-aided design, synthesis and biological evaluation of novel 4-(imidazo[1,2-a]pyridine-3‑carbonyl) phenyl urea derivatives as potent FLT3 inhibitors. Bioorg Chem. 2025 Sep;164:108912.  [Content Brief]