2. Neuronal Signaling Stem Cell/Wnt
  3. Notch
  4. Notch 1

Notch 1 (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types.

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Notch 1

Notch 1 Chemical Structure

CAS No. : 2408730-51-6

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Based on 1 publication(s) in Google Scholar

Other Forms of Notch 1:

Notch 1 Related Antibodies

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Description

Notch 1 (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types[1].

In Vitro

Notch 1 is shown to promote mouse luminal prostate cell survival and proliferation through the activation of the prosurvival NF-κB pathway[2].
Down-regulation of Notch 1 and Jagged1 in human prostate cancer cell lines decreases in vitro invasion and cell growth[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Notch 1 Related Antibodies
Molecular Weight

1500.72

Formula

C62H97N15O22S3
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Cys-Leu-Asp-Gln-Ile-Gly-Glu-Phe-Gln-Cys-Ile-Cys-Glu
Sequence Shortening

CLDQIGEFQCICE
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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Notch 1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Notch 12408730-51-6Notch1Notch-1NotchInhibitorinhibitorinhibit

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Notch 1
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HY-P1985
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