2. Metabolic Enzyme/Protease Apoptosis Cell Cycle/DNA Damage
  3. Carbonic Anhydrase Apoptosis CDK
  4. Carbonic anhydrase inhibitor 33

Carbonic anhydrase inhibitor 33 (11D) is a dual Inhibitor of CA (Carbonic anhydrase) IX/XII and CDK6, with Ki values of 19.7 nM and 26.1 nM for hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor 33 (11D) induces G1 arrest and apoptosis. Carbonic anhydrase inhibitor 33 (11D) can be used in the research for NSCLC.

For research use only. We do not sell to patients.

Carbonic anhydrase inhibitor 33 Chemical Structure

Carbonic anhydrase inhibitor 33 Chemical Structure

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Carbonic anhydrase inhibitor 33 Related Antibodies

Top Publications Citing Use of Products

View All Carbonic Anhydrase Isoform Specific Products:

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CA CA I CA Ⅱ CA IX CA XII

View All CDK Isoform Specific Products:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

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Description

Carbonic anhydrase inhibitor 33 (11D) is a dual Inhibitor of CA (Carbonic anhydrase) IX/XII and CDK6, with Ki values of 19.7 nM and 26.1 nM for hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor 33 (11D) induces G1 arrest and apoptosis. Carbonic anhydrase inhibitor 33 (11D) can be used in the research for NSCLC[1].

IC50 & Target[1]

hCA IX

19.7 nM (Ki)

hCA XII

26.1 nM (Ki)

hCA II

76.1 nM (Ki)

hCA I

663 nM (Ki)

CDK6

0.069 μM (IC50)

In Vitro

Carbonic anhydrase inhibitor 33 (11D) exhibits IC50 values of 2.39 μM and 7.92 μM in A549 and NCI-H1734 cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Carbonic anhydrase inhibitor 33 Related Antibodies
Molecular Weight

410.42

Formula

C19H15FN6O2S
SMILES

O=S(C1=CC=C(/N=N/C2=C3N=CC=C(C4=CC=C(F)C=C4)N3N=C2C)C=C1)(N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Carbonic anhydrase inhibitor 33 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Carbonic anhydrase inhibitor 33Carbonic anhydrase inhibitor33Carbonic anhydrase inhibitor-33Carbonic AnhydraseApoptosisCDKCarbonate dehydrataseCyclin dependent kinaseNSCLChCA IXhCA XIIInhibitorinhibitorinhibit

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