2. Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Apoptosis Reactive Oxygen Species (ROS)
  4. Apoptosis inducer 41

Apoptosis inducer 41 is an apoptosis inducer that induces apoptosis through the mitochondrial pathway. Apoptosis inducer 41 exhibits remarkable inhibitory effects against MCF-7 cells (IC50 = 6.2 μM). Apoptosis inducer 41 significantly arrests MCF-7 cells in the G2/M phase, increases ROS accumulation, induces mitochondrial membrane potential depolarization. Apoptosis inducer 41 can used for the study of breast cancer.

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Apoptosis inducer 41

Apoptosis inducer 41 Chemical Structure

CAS No. : 3085940-57-1

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Apoptosis inducer 41 Related Antibodies

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Description

Apoptosis inducer 41 is an apoptosis inducer that induces apoptosis through the mitochondrial pathway. Apoptosis inducer 41 exhibits remarkable inhibitory effects against MCF-7 cells (IC50 = 6.2 μM). Apoptosis inducer 41 significantly arrests MCF-7 cells in the G2/M phase, increases ROS accumulation, induces mitochondrial membrane potential depolarization. Apoptosis inducer 41 can used for the study of breast cancer[1].

In Vitro

Apoptosis inducer 41 (Compound 6j) (1‑100 μM, 48 h) exhibits antiproliferative activities in various cells with IC50s of 7.1, 40.9, 6.2 and 46.1 against MDA-MB-231, MDA-MB-468, MCF-7 and MCF-10A cells[1].
Apoptosis inducer 41 (1-9 μM, 24-48 h) significantly induces MCF-7 apoptosis through the mitochondrial apoptosis pathway and arrests cells in the G2/M phase[1].
Apoptosis inducer 41 (1-9 μM, 24 h) induces ROS generation and impaires mitochondrial membrane potential (MMP)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis inducer 41 Related Antibodies

Apoptosis Analysis[1]

Cell Line: MCF-7 cells
Concentration: 1, 3 and 9 nM
Incubation Time: 48 h
Result: Observed the presence of nuclear collapse and the enhancement of red and bright blue fluorescence.
Increased the early apoptosis rates of MCF-7 cells ranged from 1.92% to 16.87%, while the late apoptosis rates ranged from 0.23% to 19.43%.

Cell Cycle Analysis[1]

Cell Line: MCF-7 cells
Concentration: 1, 3 and 9 nM
Incubation Time: 24 h
Result: Promoted the G2/M phase block in a concentration-dependent manner.

Western Blot Analysis[1]

Cell Line: MCF-7 cells
Concentration: 1, 3 and 9 nM
Incubation Time: 48 h
Result: Significantly upregulated the levels of cytochrome c and cleaved caspase 8.
Increased the ratio of cleaved PARP to PARP.

Immunofluorescence[1]

Cell Line: MCF-7 cells
Concentration: 1, 3 and 9 nM
Incubation Time: 24 h
Result: Increased the ROS levels by 30.67 %, 65.33 %, and 168.00 %, respectively.
Caused the MMP of MCF-7 cells depolarizes with increasing concentrations, which is characterized by a gradual decrease in the red/green fluorescence ratio.
Molecular Weight

721.77

Formula

C39H53BrN4O4
CAS No.
SMILES

C[C@@]12[C@](C[C@@]3([H])[C@]2([H])[C@@H]([C@H](O3)CC[C@@H](C)C(NCC4=CN(N=N4)CC5=CC=C(C=C5)Br)=O)C)([H])[C@@]6([H])[C@]([C@@]7(C(C[C@H](CC7)OC(C)=O)=CC6)C)([H])CC1
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Apoptosis inducer 41 Related Classifications

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Keywords:

Apoptosis inducer 413085940-57-1Apoptosis inducer41Apoptosis inducer-41ApoptosisReactive Oxygen Species (ROS)Diosgenin derivatives1,2,3-TriazoleAnti-breast cancerInhibitorinhibitorinhibit

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