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  4. Fibrinopeptide A, human TFA

Fibrinopeptide A, human TFA  (Synonyms: Human fibrinopeptide A TFA)

Cat. No.: HY-P1538A
Handling Instructions Technical Support

Fibrinopeptide A, human TFA is a 16-residue short polypeptide cleaved from fibrinogen by thrombin. Fibrinopeptide A, human locates at the NH2-termini of the Aα chain.

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Fibrinopeptide A, human TFA

Fibrinopeptide A, human TFA Chemical Structure

CAS No. : 61533-47-9

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Based on 1 publication(s) in Google Scholar

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Description

Fibrinopeptide A, human TFA is a 16-residue short polypeptide cleaved from fibrinogen by thrombin. Fibrinopeptide A, human locates at the NH2-termini of the Aα chain[1].

In Vitro

The conversion of monomeric fibrinogen into polymeric fibrin is mediated by thrombin, which binds to the central region of fibrinogen and catalyzes cleavage of the 2 short peptides, the 16-residue fibrinopeptide A (FpA) and the 14-residue fibrinopeptide B (FpB), located at the NH2-termini of the Aα and Bβ chains, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Fibrinopeptide A (FPA) is a small polypeptide cleaved from fibrinogen by thrombin, has a short half-life, and is considered a sensitive biochemical marker of thrombin activity, fibrin generation, and ongoing thrombosis[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1764.60

Formula

C63H97N19O26.2C2HF3O2

CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ala-Asp-Ser-Gly-Glu-Gly-Asp-Phe-Leu-Ala-Glu-Gly-Gly-Gly-Val-Arg

Sequence Shortening

ADSGEGDFLAEGGGVR

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (56.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5667 mL 2.8335 mL 5.6670 mL
5 mM 0.1133 mL 0.5667 mL 1.1334 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.5667 mL 2.8335 mL 5.6670 mL 14.1675 mL
5 mM 0.1133 mL 0.5667 mL 1.1334 mL 2.8335 mL
10 mM 0.0567 mL 0.2834 mL 0.5667 mL 1.4168 mL
15 mM 0.0378 mL 0.1889 mL 0.3778 mL 0.9445 mL
20 mM 0.0283 mL 0.1417 mL 0.2834 mL 0.7084 mL
25 mM 0.0227 mL 0.1133 mL 0.2267 mL 0.5667 mL
30 mM 0.0189 mL 0.0945 mL 0.1889 mL 0.4723 mL
40 mM 0.0142 mL 0.0708 mL 0.1417 mL 0.3542 mL
50 mM 0.0113 mL 0.0567 mL 0.1133 mL 0.2834 mL
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Fibrinopeptide A, human TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Fibrinopeptide A, human TFA
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